1111072-17-3

Upstream product

• 82203-83-6 1-(p-methoxyphenyl)-3,3,3-trifluoropropyne 
• 2314-97-8 iodotrifluoromethane 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1111072-32-2 (E)-4-(4-methoxyphenyl)-N,N-diethyl-6,6,6-trifluorohex-4-en-2-yl-1-amine 
• 1111072-34-4 (E)-1-phenyl-3-(4-methoxyphenyl)-5,5,5-trifluoropent-3-en-1-yl 
• 1111072-35-5 (E)-5-(4-methoxyphenyl)-7,7,7-trifluoro-2-methylhept-5-en-3-yl-2-ol 

Relevant academic research and scientific papers

Controlled trifluoromethylation reactions of alkynes through visible-light photoredox catalysis

The control of a reaction that can form multiple products is a highly attractive and challenging concept in synthetic chemistry. A set of valuable CF3-containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, and alkynes, were selectively generated from alkynes and CF 3I by environmentally benign and efficient visible-light photoredox catalysis. Subtle differences in the combination of catalyst, base, and solvent enabled the control of reactivity and selectivity for the reaction between an alkyne and CF3I. Variety through selectivity: Highly valuable trifluoromethylated alkenyl iodides, alkenes, and alkynes were selectively generated from alkynes and CF3I by environmentally benign and efficient visible-light photoredox catalysis. A suitable choice of catalyst, base, and solvent was crucial for the reactivity and selectivity of these processes.

Regio- and stereo-specific preparation of (E)-1-aryl-3,3,3-trifluoro-1-iodo-propenes and their palladium-catalyzed reaction with terminal alkynes

A new type of iodo-containing trifluoromethylated building blocks were synthesized. The reaction of 1-aryl-3,3,3-trifluoropropynes 1 with lithium iodide in acetic acid at 75 °C gave (E)-1-aryl-3,3,3-trifluoro-1-iodo-propenes 2 in high yield, which undergo the palladium-catalyzed Sonogashira reaction with terminal alkynes afforded trifluoromethyl-containing 1,3-enynes in high yield.