1111165-33-3Relevant academic research and scientific papers
Gold-catalyzed cycloisomerization of pyridine-bridged 1,8-diynes: An expedient access to luminescent cycl[3.2.2]azines
Chintawar, Chetan C.,Mane, Manoj V.,Tathe, Akash G.,Biswas, Suprakash,Patil, Nitin T.
supporting information, p. 7109 - 7113 (2019/09/30)
Gold-catalyzed diyne cycloisomerizations involving carbene/alkyne metathesis have been the focal point of attention for the past few years as it offers great potential to build complex polycyclic architectures. However, the design of novel cycloisomerizations has been mostly limited to 1,5/1,6-diynes and has remained very challenging to apply for higher 1,n-diynes. Herein, we disclose an unprecedented cycloisomerization of pyridine-bridged 1,8-diynes involving carbene/alkyne metathesis to access luminescent cycl[3.2.2]azines.
Synthetic method of pyridine [2,1-a] isoindole compound
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Paragraph 0019, (2018/04/02)
The invention provides a synthetic method of a pyridine [2,1-a] isoindole compound, which belongs to the technical field of organic synthesis. The method comprises the following steps: 1) phenylpyridine or a derivative a, bromoacetophenone or a derivative b, a cobalt/copper co-catalysis system and caesium salt are added in a reaction tube in order, and a solvent is added in the reaction tube; 2) the reaction tube is reacted under air condition at the temperature of 120-140 DEG C, wherein the reaction time is greater than or equal to 24 h; 3) a reaction mixture is filtered after the reaction iscompleted, the mixture is concentrated, the mixture is separated through column chromatography, and petroleum ether/ethyl acetate mixed liquor is washed to obtain the [2,1-a] isoindole compound c. The phenylpyridine or its derivative, bromoacetophenone or the derivative are taken as the reaction objects, the reaction is carried out under the cobalt-copper co-catalysis system, the reaction condition is mild, the reaction is easy to carry out, the cost of the catalysis system is low, the substrate universality is strong, and the yield is high.
A [4 + 1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp2-H Bond Functionalization
Chen, Xun,Hu, Xinwei,Deng, Yuanfu,Jiang, Huanfeng,Zeng, Wei
supporting information, p. 4742 - 4745 (2016/09/28)
A Co(III)-catalyzed [4 + 1] cycloaddition of 2-arylpyridines or 2-alkenylpyridines with aldehydes through Csp2-H bond activation has been developed. This protocol provides a facile approach to structurally diverse indolizines including benzoind
Rhodium-Catalyzed Direct Oxidative C-H Acylation of 2-Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1-a]isoindoles
Zhao, Binlin,Yu, Mengxuan,Liu, Hui,Chen, Yu,Yuan, Yu,Xie, Xuejian
supporting information, p. 3295 - 3301 (2015/02/02)
A synthesis of pyrido[2,1-a]isoindoles is reported by the rhodium-catalyzed direct oxidative CH acylation of 2-aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This is an efficient and clean method to construct C-C/C-N bonds in one step. In addition, the effective rhodium(III) catalyst was isolated and characterized by X-ray crystallography.
Facile synthesis of pyrido[2,1- a ]isoindoles via iron-mediated 2-arylpyridine C-H bond cleavage
Liu, Shan,Hu, Xingen,Li, Xinhua,Cheng, Jiang
, p. 847 - 850 (2013/05/22)
An iron-catalyzed reaction of 2-arylpyridine C-H bond with 2-bromoacetophenone is achieved, providing pyrido[2,1-a]-isoindoles in moderate to good yields. The regioselectivity stems from the domination of hindrance on the regioselective ortho-functionalization of 2-arylpyridines C-H bond. Georg Thieme Verlag Stuttgart · New York.
