111128-27-9 Usage
Uses
Used in Anticancer Applications:
Bupleurotoxin is used as an antineoplastic agent for its ability to target and inhibit the growth of cancer cells. Its phytogenic origin suggests that it may offer a natural alternative or complementary approach to conventional cancer treatments, potentially with fewer side effects and improved patient outcomes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, bupleurotoxin is used as a key component in the development of novel cancer therapies. Its unique chemical properties and antineoplastic effects make it a valuable candidate for further research and potential incorporation into new drug formulations.
Used in Drug Delivery Systems:
Similar to gallotannin, bupleurotoxin can also be utilized in drug delivery systems to enhance its bioavailability and therapeutic efficacy. By employing various organic and metallic nanoparticles as carriers, the delivery, targeting, and overall effectiveness of bupleurotoxin in cancer treatment can be improved.
Check Digit Verification of cas no
The CAS Registry Mumber 111128-27-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,1,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 111128-27:
(8*1)+(7*1)+(6*1)+(5*1)+(4*2)+(3*8)+(2*2)+(1*7)=69
69 % 10 = 9
So 111128-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H22O2/c1-2-14-17(19)15-12-10-8-6-4-3-5-7-9-11-13-16-18/h4,6,8,10-11,13,17-19H,2,12,14-16H2,1H3/b6-4+,10-8+,13-11-
111128-27-9Relevant academic research and scientific papers
Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues
Sommerwerk, Sven,Heller, Lucie,Siewert, Bianka,Csuk, René
, p. 5595 - 5602 (2015/11/11)
We developed a synthetic scheme for the synthesis of naturally occurring (14R)-oenanthotoxin and several analogs. Key-steps of this synthesis were an efficient homo-coupling of alkynes and a chemoenzymatic resolution of racemic oenanthotoxin using novozyme 435 and vinyl acetate. The compounds were screened for their cytotoxic activity using a photometric sulforhodamine B assays and several human tumor cell lines. Oenanthotoxin and many derivatives thereof were cytotoxic to tumor cell lines as well as to non-malignant mouse fibroblasts. The highest activity was determined for human ovarian cancer cells A2780 with EC50 = 3.8 μM.
