11113-80-7 Usage
Uses
Used in Agriculture:
Polyoxin is used as a fungicide for the control of various plant diseases caused by fungi such as Alternaria spp., Rhizoctonia spp., and powdery mildews. It is effective against a wide range of crops, including apples, pears, vines, aubergines, roses, chrysanthemums, melons, carnations, tobacco, strawberries, tomatoes, cucumbers, carrots, and leeks.
Polyoxin B is used as a fungicide for the control of Alternaria spp. and powdery mildews in apples and pears, Botrytis cinerea in vines and aubergines, powdery mildews in roses, chrysanthemums, and melons, blight of carnation, powdery mildew, brown spot, and gray mold in tobacco, powdery mildew and gray mold in strawberries, leaf mold, early blight, and gray mold in tomatoes, powdery mildew, gray mold, Sclerotinia erotinia spp. rot, and Corynespora melonis in cucumbers, Alternaria spp. blight in carrots, and purple blotch in leeks.
Polyoxin D zinc salt is used as a fungicide for the control of sheath blight (Rhizoctonia solani) in rice, canker in apples and pears, and various fungal pathogens such as Rhizoctonia solani, Drechslera spp., Bipolaris spp., Curvularia spp., and Helminthosporium spp. in lawn turf.
Formulation types for Polyoxin include WP (Wettable Powder), EC (Emulsifiable Concentrate), and SG (Soluble Granules). It can be mixed with other fungicides such as captan, oxine-copper, and iminoctadine triacetate for enhanced control. However,
Metabolism
Polyoxin B causes a marked abnormal swelling on germ
tubes of spores and hyphal tips in Alternaria spp.,
and this makes the pathogen noninfectious. In a cellfree
system of Neurospora crassa, polyoxin D inhibits
the incorporation of N-acetyl-glucosamine (GlcNAc) into
chitin in a competitive manner between UDP-GlcNAc
and polyoxin D; the pyrimidine nucleoside moiety of the
antibiotics was shown to fit into the binding site of the
enzyme protein, and the carbamoylpolyoxamic acid moiety
of polyoxins stabilizes the polyoxin-enzyme complex (26).
Polyoxin-resistant strains of A. alternata were recognized
in pear orchards after several years of intensive
use of the antibiotics. The resistance was suggested to be
caused by a lowered permeability of the antibiotic through
the cell membrane into the site of chitin synthesis (27).
Toxicity evaluation
Acute oral LD50 of polyoxin B for male rats 21, female
rats 21.2, male mice 27.3, and femalemice 22.5 g/kg. Acute
percutaneous LD50 for rats >2 g/kg. Nonirritant to mucous
membranes and skin (rats). Inhalation LD50 (6 h) for rats
10 mg/L air. NOEL (2 y) for rats and mice >48-g/kg diet.
Toxicity class EPA (formulation) IV.
Acute oral LD50 of polyoxin D for male rats and
female rats >9.6 g/kg. Acute percutaneous LD50 for rats
>750 mg/kg. Inhalation LD50 (4 h) for male rats 2.44,
female rats 2.17 mg/L air. NOEL (2 y) for rats >50, mice
>40 g/kg diet. Toxicity class EPA (formulation) III (WP).
Check Digit Verification of cas no
The CAS Registry Mumber 11113-80-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,1,1 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 11113-80:
(7*1)+(6*1)+(5*1)+(4*1)+(3*3)+(2*8)+(1*0)=47
47 % 10 = 7
So 11113-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N3O8/c12-4(2-15)7-5(16)6(17)9(22-7)14-1-3(10(19)20)8(18)13-11(14)21/h1-2,4-7,9,16-17H,12H2,(H,19,20)(H,13,18,21)/t4?,5-,6+,7+,9+/m0/s1
