11113-80-7 Usage
Uses
The fungicidal activities of polyoxins reported on many
plant pathogens, including Alternaria spp. and Rhizoctonia
zoctonia spp. (24,25).
Polyoxin B is used for control of Alternaria spp.
and powdery mildews in apples and pears; Botrytis
cinerea in vines and aubergines; powdery mildews in
roses, chrysanthemums, and melons; blight of carnation;
powdery mildew, brown spot, and gray mold in tobacco;
powdery mildew and gray mold in strawberries; leaf mold,
early blight, and gray mold in tomatoes; powdery mildew,
gray mold, Sclerotinia erotinia spp. rot, and Corynespora
melonis in cucumbers; Alternaria spp. blight in carrots;
purple blotch in leeks. Patent: JP 493008 Formulation
types: WP; EC; SG. Mixes with captan; oxine-copper;
iminoctadine triacetate. Compatibility: Incompatible with
alkaline materials. Tradename “Polyoxin AL.”
Polyoxin D zinc salt is used for control of sheath
blight (Rhizoctonia solani) in rice; canker in apples
and pears; Rhizoctonia solani, Drechslera spp., Bipolaris
spp., Curvularia spp., and Helminthosporium spp. in
lawn turf. Formulation types: WP; PA. Mixes with
thiram; propiconazole. Compatibility: Incompatible with
alkaline materials. Tradenames “Kakengel” (zinc salt);
“Polyoxin Z” (zinc salt); “Stopit.”
Application of polyoxins can be made at any growth
stage of rice plants without causing phytotoxicity even at
800-ppm application. Foliar sprays of 200 ppm of polyoxins
have produced no phytotoxicity on all the other crops
tested.
Metabolism
Polyoxin B causes a marked abnormal swelling on germ
tubes of spores and hyphal tips in Alternaria spp.,
and this makes the pathogen noninfectious. In a cellfree
system of Neurospora crassa, polyoxin D inhibits
the incorporation of N-acetyl-glucosamine (GlcNAc) into
chitin in a competitive manner between UDP-GlcNAc
and polyoxin D; the pyrimidine nucleoside moiety of the
antibiotics was shown to fit into the binding site of the
enzyme protein, and the carbamoylpolyoxamic acid moiety
of polyoxins stabilizes the polyoxin-enzyme complex (26).
Polyoxin-resistant strains of A. alternata were recognized
in pear orchards after several years of intensive
use of the antibiotics. The resistance was suggested to be
caused by a lowered permeability of the antibiotic through
the cell membrane into the site of chitin synthesis (27).
Toxicity evaluation
Acute oral LD50 of polyoxin B for male rats 21, female
rats 21.2, male mice 27.3, and femalemice 22.5 g/kg. Acute
percutaneous LD50 for rats >2 g/kg. Nonirritant to mucous
membranes and skin (rats). Inhalation LD50 (6 h) for rats
10 mg/L air. NOEL (2 y) for rats and mice >48-g/kg diet.
Toxicity class EPA (formulation) IV.
Acute oral LD50 of polyoxin D for male rats and
female rats >9.6 g/kg. Acute percutaneous LD50 for rats
>750 mg/kg. Inhalation LD50 (4 h) for male rats 2.44,
female rats 2.17 mg/L air. NOEL (2 y) for rats >50, mice
>40 g/kg diet. Toxicity class EPA (formulation) III (WP).
Check Digit Verification of cas no
The CAS Registry Mumber 11113-80-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,1,1 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 11113-80:
(7*1)+(6*1)+(5*1)+(4*1)+(3*3)+(2*8)+(1*0)=47
47 % 10 = 7
So 11113-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N3O8/c12-4(2-15)7-5(16)6(17)9(22-7)14-1-3(10(19)20)8(18)13-11(14)21/h1-2,4-7,9,16-17H,12H2,(H,19,20)(H,13,18,21)/t4?,5-,6+,7+,9+/m0/s1
