1111300-72-1Relevant academic research and scientific papers
Copper-catalyzed oxybromination and oxychlorination of primary aromatic amines using LiBr or LiCl and molecular oxygen
Menini, Luciano,Da Cruz Santos, Joyce C.,Gusevskaya, Elena V.
, p. 2052 - 2058 (2008)
Nuclear oxybromination of unprotected aromatic primary amines catalyzed by copper(II) acetate [Cu(OAc)2] under mild conditions has been developed, in which bromide ions are used as halogenating agents and dioxygen as a final oxidant. The catalyst shows not only high regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Oxychlorination of aniline can also be performed under similar conditions, albeit with lower selectivities, with N-phenylacetamide being the main by-product. This simple catalytic method represents ecologically benign and economically attractive synthetic pathway to expensive low-volume aromatic haloamines.
MODULATORS OF CCR9 RECEPTOR AND METHODS OF USE THEREOF
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Page/Page column 33-34, (2010/03/02)
Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated
