111138-00-2Relevant academic research and scientific papers
Synthesis and biophysical evaluation of 3′-Me-α-l-LNA - Substitution in the minor groove of α-l-LNA duplexes
Seth, Punit P.,Allerson, Charles A.,stergaard, Michael E.,Swayze, Eric E.
, p. 4690 - 4694 (2011/09/20)
The synthesis and biophysical evaluation of 3′-Me-α-l-LNA is reported. The synthesis of the nucleoside building block phosphoramidite was accomplished starting from diacetone glucose. The 3′-Me group was introduced in the desired configuration by hydride
