111138-53-5

Usage

Uses

Used in Pharmaceutical Industry:
TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER is used as a building block for the synthesis of various drugs, particularly those targeting the central nervous system, due to its role as an intermediate in the synthesis of the neurotransmitter glutamate.
Used in Chemical Research:
TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER is used as a reagent in organic synthesis, contributing to the development of new chemical compounds and processes.
Used in Organic Synthesis:
TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER is used as a reagent in organic synthesis, facilitating the creation of new compounds and enhancing the understanding of chemical reactions and mechanisms.
Safety Precautions:
It is important to handle TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER with caution, as it may possess hazardous properties. TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER should be kept away from heat, sparks, and open flames to prevent potential accidents or hazards.

Upstream product

• 50-00-0 formaldehyd 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 56-40-6 glycine 
• 624-49-7 dimethylfumarate 
• 186581-53-3 diazomethane 
• 87813-05-6 dimethyl (3R,4R)-1-benzylpyrrolidine-3,4-dicarboxylate 
• 111051-20-8 (3R,4R)-Pyrrolidine-3,4-dicarboxylic acid monomethyl ester 

Downstream Products

• 1782350-51-9 racemic trans-1-(tert-butoxycarbonyl)pyrrolidine-3,4-dicarboxylic acid 
• 111186-67-5 dimethyl trans-1-benzylpyrrolidine-3,4-dicarboxylate 

Relevant academic research and scientific papers

Mechanism-Inspired Design of Bifunctional Catalysts for the Alternating Ring-Opening Copolymerization of Epoxides and Cyclic Anhydrides

Advances in catalysis have enabled the ring-opening copolymerization of epoxides and cyclic anhydrides to afford structurally and functionally diverse polyesters with controlled molecular weights and dispersities. However, the most common systems employ b

Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation

The preparation and evaluation of a series of inhibitors of Myc/Max dimerization and Myc-induced cell transformation are described providing mycmycin-1 (3) and mycmycin-2 (4).

PROCESSES FOR THE PREPARATION OF (3R, 4R) -N- (4 -CHLOROPHENYL) -1- (2, 2-DIFLUOROETHYL) -N' - [2-FLUORO-4- (2-OXO-1 (2H) -PYRIDINYL) PHENYL] -3, 4-PYRROLIDINEDICARBOXAMIDE

The invention is concerned with processes for the manufacture of pyrrolidine-3,4- dicarboxamide derivative of formula (I), and the intermediates useful for those processes.

Chemoenzymatic preparation of non-racemic N-Boc-pyrrolidine-3,4-dicarboxylic acid 3-ethyl esters and their 4-hydroxymethyl derivatives

For the synthesis of metalloproteinase inhibitors the (R,R)- and (S,S)-monoethyl esters of N-Boc-pyrrolidine-3,4-dicarboxylic acid were prepared as key intermediates from the trans-diester racemate by two consecutive, highly selective enzymatic reactions.

Parent and N-substitued azomethine ylides from α-amino acids and formaldehyde. An easy access to 2,5-unsubstituted pyrrolidines. Evidence for oxazolidin-5-ones as direct precursor of these reactive intermediates

Formaldehyde reacts with α-amino acids and electron deficient alkenes to produce pyrrolidines.Azomethine ylides involved as intermediates in these reactions have been generated from isolated oxazolidin-5-ones which can be considered as the direct precursors of these ylides.

Simple Generation of Nonstabilized Azomethine Ylides through Decarboxylative Condensation of α-Amino Acids with Carbonyl Compounds via 5-Oxazolidinone Intermediates

Heating α-amino acids with a variety of carbonyl compounds generates N-unsubstituted or N-substituted azomethine ylides of nonstabilized types through the elimination of water and carbon dioxide.The ylides are captured by olefinic, acetylenic, and carbonyl dipolarophiles producing pyrrolidines, pyrrolines, and oxazolidines.The reaction involves intermediary 5-oxazolidinones which can be sometimes isolated.Some synthetic equivalents of parent azomethine ylide, methaniminium methylide, are accessible by this route.

2,5-Unsubstituted Pyrrolidines from Formaldehyde and Amino Acids through in situ Azomethine-ylide 1,3-Dipolar Cycloaddition to Alkenes

Formaldehyde and α-amino acids such as sarcosine and glycine react with alkenes to give N-Me and N-H pyrrolidines via in situ generated azomethine-ylides.