111164-76-2Relevant academic research and scientific papers
An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles
Engler, Thomas A.,Furness, Kelly,Malhotra, Sushant,Diefenbacher, Clive,Clayton, Joshua R.
, p. 2903 - 2905 (2003)
Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.
