22960-16-3

Basic information

• Product Name: Isoquinoline-4-carbaldehyde
• Synonyms: RARECHEM AK ML 0134;ISOQUINOLINE-4-CARBALDEHYDE;4-ISOQUINOLINECARBOXALDEHYDE;4-Isoquinolinecarboxaldehyde (7CI,8CI,9CI);4-Formylisoquinoline;Isoquinoline-4-carboxaldehyde;Isoquinoline-4-carbaldehyde ,98%;4-Isoquinolinecarboxaldehyde 97%
• CAS NO: 22960-16-3
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.17
• Product Categories: ALDEHYDE;Carbonyl Compounds;Heterocycles;Isoquinoline Derivertives;Building Blocks;Isoquinoline
• Mol File: 22960-16-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 101-106℃
• Boiling Point: 331.718 °C at 760 mmHg
• Flash Point: 162.428 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: Isoquinoline-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline-4-carbaldehyde(22960-16-3)
• EPA Substance Registry System: Isoquinoline-4-carbaldehyde(22960-16-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-22
• RIDADR: 2811
• WGK Germany: 3
• Hazardous Substances Data: 22960-16-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to yellow or brown solid

InChI:InChI=1/C10H7NO/c12-7-9-6-11-5-8-3-1-2-4-10(8)9/h1-7H

Upstream product

• 1532-97-4 4-bromoisoquinoline 
• 32117-82-1 N-methoxy-N-methyl-formamide 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 109-72-8 n-butyllithium 
• 68-12-2 N,N-dimethyl-formamide 
• 330435-61-5 2,2-dimethyl-5-(2-formylphenyl)-4H-1,3-dioxin 

Downstream Products

• 112518-81-7 4-Formyl-1-prop-2-ynyl-1H-isoquinoline-2-carboxylic acid methyl ester 
• 73048-60-9 4-(hydroxymethyl)isoquinoline 
• 370580-21-5 4-isochinolinyl-(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)-methanol 
• 111164-76-2 2--acetonitril 
• 20335-71-1 3-benzoylisoquinoline 
• 372077-34-4 4-isochinolinyl-(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)-methanone 

Relevant articles and documents

INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT

The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer, reducing inflammation and/or treating an autoimmune or inflammatory disease.

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.