1111754-91-6Relevant academic research and scientific papers
Asymmetric synthesis of 5-(1-hydroxyalkyl)tetrazoles by catalytic enantioselective passerini-type reactions
Yue, Tao,Wang, Mei-Xiang,Wang, De-Xian,Zhu, Jieping
, p. 9454 - 9457 (2008)
(Chemical Equation Presented) Three-part harmony: Three-component Passerini reactions (P-3CR, see Scheme) of a wide range of aldehydes 2 and isocyanides 3, with hydrazoic acid 4 in toluene, in the presence of a [(salen)AlMe]-complex catalyst afford 5-(1-hydroxyalkyl)tetrazoles 1 in good-to-excellent yields and enantiomeric excess. A tandem Michael addition/enantioselective P-3CR, using an acrolein substrate, affords highly functionalized tetrazoles.
