1111791-59-3Relevant academic research and scientific papers
Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation
Saraogi, Ishu,Hebda, James A.,Becerril, Jorge,Estroff, Lara A.,Miranker, Andrew D.,Hamilton, Andrew D.
supporting information; scheme or table, p. 736 - 739 (2010/05/01)
Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.
Controlling curvature in a family of oligoamide α-helix mimetics
Saraogi, Ishu,Incarvito, Christopher D.,Hamilton, Andrew D.
supporting information; experimental part, p. 9691 - 9694 (2009/05/30)
(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices.
