1111791-75-3Relevant articles and documents
Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions
Murphy, Natasha S.,Prabhakaran, Panchami,Azzarito, Valeria,Plante, Jeffrey P.,Hardie, Michaele J.,Kilner, Colin A.,Warriner, Stuart L.,Wilson, Andrew J.
, p. 5546 - 5550 (2013/06/27)
Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenyl
Controlling curvature in a family of oligoamide α-helix mimetics
Saraogi, Ishu,Incarvito, Christopher D.,Hamilton, Andrew D.
supporting information; experimental part, p. 9691 - 9694 (2009/05/30)
(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices.