111187-01-0

Upstream product

• 105447-18-5 4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-4-methyl-pentanoic acid tert-butyl ester 
• 137161-74-1 (2S)-3,3-dimethylbutane-1,2,4-triol 
• 105447-16-3 2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methyl-propan-1-ol 
• 79-50-5 (S)-pantolactone 
• 105447-17-4 2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methyl-propionaldehyde 
• 105447-19-6 (S)-4-Hydroxy-6-hydroxymethyl-5,5-dimethyl-tetrahydro-pyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 111080-23-0 (S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(1-ethoxy-ethoxy)-5,5-dimethyl-tetrahydro-pyran-2-one 
• 111080-15-0 2-[(2R,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-2-methoxy-5,5-dimethyl-tetrahydro-pyran-2-yl]-propionic acid isopropyl ester 
• 111080-15-0 2-[(2R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-2-methoxy-5,5-dimethyl-tetrahydro-pyran-2-yl]-propionic acid isopropyl ester 
• 111080-22-9 (S)-3-((2S,5S,6R)-6-tert-Butoxy-5-methyl-tetrahydro-pyran-2-yl)-1-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butan-2-ol 
• 111085-59-7 (S)-3-((2S,5R,6R)-6-tert-Butoxy-5-methyl-tetrahydro-pyran-2-yl)-1-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butan-2-ol 
• 111080-20-7 Benzoic acid (4R,6S,9R)-2-benzenesulfonyl-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-9-[1,3]dithian-2-yl-5,5-dimethyl-1-((2S,4S,5R)-5-methyl-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl)-decyl ester 
• 115378-67-1 (4R,6S,9R)-2-Benzenesulfonyl-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-9-[1,3]dithian-2-yl-5,5-dimethyl-1-((2S,4S,5R)-5-methyl-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl)-decan-1-ol 
• 116903-79-8 Acetic acid (S)-2-((S)-4-acetoxy-5-methyl-6-oxo-tetrahydro-pyran-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-propyl ester 
• 111080-24-1 2-[(S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(1-ethoxy-ethoxy)-2-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-yl]-propionic acid isopropyl ester 
• 111080-14-9 2-[(2R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5,5-dimethyl-4-oxo-tetrahydro-pyran-2-yl]-propionic acid isopropyl ester 
• 111080-16-1 (5S,7S)-8-(tert-Butyl-diphenyl-silanyloxy)-3,5,7-trihydroxy-2,6,6-trimethyl-octanoic acid isopropyl ester 
• 111080-17-2 Acetic acid (S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-2-((S)-5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-propyl ester 
• 111080-18-3 (S)-3-((2S,6R)-6-tert-Butoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl)-1-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butan-2-ol 
• 116903-78-7 (S)-6-[(S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-1,1-dimethyl-propyl]-4-hydroxy-3-methyl-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

SYNTHETIC STUDIES ON (+)-APLASMOMYCIN. 2. STEREOSELECTIVE SYNTHESIS OF COREY'S KEY INTERMEDIATE, A FORMAL TOTAL SYNTHESIS

The C-3 - C-11 segment 2 of (+)-aplasmomycin was synthesized stereoselectively starting from (+)-pantolactone (4) and the C-3 - C-17 segment 3 was synthesized via coupling of 1 and 2.