111197-80-9

Upstream product

• 24347-63-5 methyl (S)-2-hydroxy-3-methylbutanoate 
• 111199-07-6 (S)-2-hydroxy-3,N,N-trimethylbutanamide 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 72-18-4 L-valine 

Downstream Products

• 111460-87-8 (S)-2-hydroxy-1-(4-methoxyphenyl)-3-methyl-1-propanone 2,2-dimethyl-trimethylene acetal 
• 111197-85-4 (S)-2-hydroxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal 
• 111197-99-0 3-hydroxy-2,2-dimethylpropyl (S)-2-(4-methoxyphenyl)-3-methylbutanoate 
• 111197-90-1 (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal 
• 111197-91-2 (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal 

Relevant academic research and scientific papers

Synthesis and Rhizopus oryzae mediated enantioselective hydrolysis of α-acetoxy aryl alkyl ketones

Mn(OAc)3 oxidation of aromatic ketones afforded the α-acetoxy ketones in good yield. Selective hydrolysis of the acetoxy ketones by the fungus Rhizopus oryzae yields (R)-hydroxy ketones in high enantiomeric excess.

A General Synthetic Method of Chiral 2-Arylalkanoic Esters via Thermal 1,2-Rearrangement

(S)-1-Aryl-2-sulfonyloxy-1-alkanone acetals, prepared from natural ethyl (S)-lactate or (S)-valine (chiral sources) by the use of a Grignard reaction, were rearranged under hydrolytic conditions in the presence of a base to give (S)-2-arylalkanoic esters which in general, showed much higher pharmacological activities than their antipodes.