111229-33-5Relevant academic research and scientific papers
Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists
Liu, Xue-Wei,Ma, Jimei,Colson, Anny-Odile,Doersen, Doreen Cross,Ebetino, Frank H.
, p. 1223 - 1228 (2008/12/21)
A series of novel peptidomimetic analogs was prepared containing cyclohexyl, phenyl, or heterocyclic groups to ostensibly orient the guanidine or mimic of an arginine in a putative melanocortin receptor ligand pharmacophore. Some binding affinity at the melanocortin receptors MC3 and MC4 was noted. In silico docking also indicated that the relative positions of the hydrogen-bonding sites and hydrophobic regions of the compounds are reasonably well matched to the receptor-binding site. This may present a lead entry into a selective series of MC4R agonists.
