1112357-67-1

Upstream product

• 73790-06-4 ethyl 2-oxo-2-(4-(trifluoromethyl)phenyl)acetate 
• 924-44-7 glyoxylic acid ethyl ester 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 1233330-10-3 methanesulfonyloxy-(4-trifluoromethyl-phenyl)-acetic acid ethyl ester 
• 1399983-78-8 (E)-ethyl 2-hydroxy-5,9-dimethyl-2-(4-(trifluoromethyl)phenyl)deca-4,8-dienoate 
• 1399983-72-2 ethyl 2-hydroxy-5-methyl-2-(4-(trifluoromethyl)phenyl)hex-4-enoate 

Relevant academic research and scientific papers

Iron-catalyzed hydrogenation for the in situ regeneration of an NAD(P)H model: Biomimetic reduction of α-Keto-/α-iminoesters

Two irons for a smoother finish: An NAD(P)H model was regenerated readily in situ by iron-catalyzed reduction with molecular hydrogen. The subsequent biomimetic reduction of α-keto-/ α-iminoesters proceeded smoothly in the presence of an iron-based Lewis acid (LA) to provide α-hydroxyesters and amino acid esters in good to excellent yields (see scheme; NAD(P) +=nicotinamide adenine dinucleotide (phosphate), TM=transition metal). Copyright

ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF

The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, to methods of preparing such derivatives, to compositions comprising them and therapeutic use thereof.

Suzuki-Miyaura coupling reaction of boronic acids and ethyl glyoxylate: Synthetic access to mandelate derivatives

The palladium-catalyzed coupling reaction of arylboronic acids with ethyl glyoxylate provides a straightforward method for the synthesis of mandelic esters. Pd2(dba)3·CHCl3 in combination with 2-di-tert-butylphosphanylbiphenyl as the catalytic system and Cs 2CO3 as the base were used. The reaction tolerates a wide range of functionalized boronic acids. Mandelic esters were isolated in good-to-excellent yields with a variety of neutral, slightly electron-rich, and slightly electron-poor substituents. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.