111247-99-5Relevant academic research and scientific papers
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers
Mavromoustakos,Calogeropoulou,Koufaki,Kolocouris,Daliani,Demetzos,Meng,Makriyannis,Balzarini,De Clercq
, p. 1702 - 1709 (2007/10/03)
The 1-O-hexadecyl-2-O-methyl-sn-glyceryl phosphodiester AZT 4 and hexadecyl-phosphodiester AZT 5 derivatives were synthesized and found to be active against HIV-1, HIV-2, and tumor cell proliferation. Compared to AZT, compound 4 possessed ca. 10-fold lowe
Stereospecific Synthesis of Ether and Thioether Phospholipids. The Use of L-Glyceric Acid as a Chiral Phospholipid Precursor
Bhatia, Suresh K.,Hajdu, Joseph
, p. 5034 - 5039 (2007/10/02)
A novel stereospecific synthesis of biologically active ether phospholipids is reported.The synthesis is based on (1) the use of L-glyceric acid as the chiral center for the construction of the optically active phospholipid molecule, (2) the introduction
A NEW APPROACH TO THE SYNTHESIS OF ETHER PHOSPHOLIPIDS. PREPARATION OF 1,2-DIALKYLGLYCEROPHOSPHORYLCHOLINES FROM L-GLYCERIC ACID
Bhatia, Suresh K.,Hajdu, Joseph
, p. 271 - 274 (2007/10/02)
A novel stereospecific synthesis of antitumor active ether phospholipids is reported.
