342883-88-9Relevant academic research and scientific papers
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers
Mavromoustakos,Calogeropoulou,Koufaki,Kolocouris,Daliani,Demetzos,Meng,Makriyannis,Balzarini,De Clercq
, p. 1702 - 1709 (2001)
The 1-O-hexadecyl-2-O-methyl-sn-glyceryl phosphodiester AZT 4 and hexadecyl-phosphodiester AZT 5 derivatives were synthesized and found to be active against HIV-1, HIV-2, and tumor cell proliferation. Compared to AZT, compound 4 possessed ca. 10-fold lowe
