111279-87-9

Upstream product

• 110-85-0 piperazine 
• 119001-09-1 6,7-Difluoro-9-cyclopropyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione 
• 119036-36-1 ethyl 1-cyclopropyl-6,7-difluoro-2-(methylsulfinyl)-4-oxo-1,4-dihydro-3-quinoline-carboxylate 
• 118959-66-3 Ethyl 3-cyclopropylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate 
• 111279-72-2 ethyl 1-cyclopropyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylate 
• 119001-08-0 Ethyl 1-cyclopropyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 

Relevant academic research and scientific papers

8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides compound and salts of Formula (I) and (II), disclosed herein, which includes compounds of Formula (A) and Formula (B) such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R

Tricyclic quinoline antineoplastic agents

Isothiazolo-quinoline derivatives are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases.

Syntheses of 6-fluoro-7-piperazin-l-yl-9-cyclopropyl- 2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione and 6-fluoro-7-piperazin-l-yl-9-p-fluorophenyl-2,3,4,9- tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione[1]

The syntheses of 6-fluoro-7-piperazin-l-yl-9-cyclopropyl (or 9-p-fluorophenyl)-2,3,4,9- tetrahydroisothiazolo[5,4-b]quinoline-3,4-diones as well as novel synthesis of isothiazolo-3(2H)-one system are described. Key steps include the regiospecific displace