1112840-98-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Iodo-3-methoxyaniline is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Dye Industry:
4-Iodo-3-methoxyaniline is utilized as an intermediate in the production of dyes, playing a role in the creation of colorants for various applications.
Used in Organic Synthesis:
4-Iodo-3-methoxyaniline is used as a building block in organic synthesis, enabling the preparation of complex organic molecules for a range of purposes.
Used in Medicinal Chemistry:
As a potential precursor for biologically active compounds, 4-Iodo-3-methoxyaniline is used in medicinal chemistry for the synthesis of compounds with potential therapeutic applications.
Used in Agricultural Chemistry:
4-Iodo-3-methoxyaniline is also employed in agricultural chemistry, where it may contribute to the development of new agrochemicals or pesticides.

InChI:InChI=1S/C7H8INO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3

Upstream product

• 7732-18-5 water 
• 7553-56-2 iodine 
• 536-90-3 m-Anisidine 
• 97-52-9 2-methoxy-4-nitrophenylamine 

Relevant academic research and scientific papers

Development of 2-thioxoquinazoline-4-one derivatives as dual and selective inhibitors of dynamin-related protein 1 (Drp1) and puromycin-sensitive aminopeptidase (PSA)

An established inhibitor ot dynamin-related protein 1 (Drp1), 3-(2,4-dichloro-5-methoxyphenyl)- 2- thioxoquinazoline-4-one (mdivi-1), was recently reported also to show potent puromycin-sensitive aminopeptidase (PSA)-inhibitory activity. Herein, we report structural development of mdivi-1 derivatives and structure-activity relationship (SAR) analysis of the synthesized compounds, as well as the structurally related PSA-specific inhibitor 3-(2,6-diethylphenyl)quinazoline-2,4-dione (PAQ-22), with the aim of identifying key structural features for inhibitory activity in order to develop selective inhibitors of Drpl, which is a potential target for treatment of Huntington's disease. Among the synthesized compounds, 3-(4-chloro3methoxyphenyl)-2-thioxoquinazoline-4-one 10g) exhibited more potent Drpl-inhibitory activity than mdivi-1 with high selectivity for Drpl over PSA.

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.