1112988-72-3Relevant academic research and scientific papers
Synthesis of 2,3,4-trisubstituted thiochromanes using an organocatalytic enantioselective tandem michael-henry reaction
Dodda, Rajasekhar,Goldman, Joshua J.,Mandal, Tanmay,Zhao, Cong-Gui,Broker, Grant A.,Tiekink, Edward R. T.
experimental part, p. 537 - 541 (2009/05/07)
Enantioenriched 2,3,4-trisubstituted thiochromanes have been synthesized by using a cupreine-catalyzed tandem Michael addition-Henry reaction between 2-mercaptobenzaldehydes and β-nitrostyrenes. Good diastereoselectivities and enantioselectivities were obtained for the title compounds, which may be further improved through a single recrystallization (up to 98% de and > 99% ee).
