294674-98-9

Upstream product

• 476199-18-5 dimethylthiocarbamic acid O-(2-formyl-5-methoxyphenyl) ester 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 476199-19-6 dimethylthiocarbamic acid S-(2-formyl-5-methoxyphenyl) ester 

Downstream Products

• 1151995-61-7 (6-methoxybenzo[b]thiophen-2-yl)(3,4,5-trimethoxyphenyl)methanone 
• 92014-05-6 2-cyano-6-methoxybenzothiophene 
• 217099-77-9 6-hydroxy-2-cyanobenzothiophene 
• 217659-33-1 2-phenylbenzo[b]thiophene-6-ol 
• 92014-01-2 2-phenyl-6-methoxybenzothiophene 
• 1112988-73-4 (2R,3S,4R)-2-(4-bromophenyl)-7-methoxy-3-nitro-thiochroman-4-ol 
• 1112988-72-3 (2R,3S,4R)-7-methoxy-3-nitro-2-phenyl-thiochroman-4-ol 
• 1020107-07-6 3,3-dicarbethoxy-2-(2-methoxyphenyl)-7-methoxythiochroman-4-ol 

Relevant academic research and scientific papers

Novel heterocyclic analogues of firefly luciferin

Five novel firefly luciferin analogues in which the benzothiazole ring system of the natural substrate was replaced with benzimidazole, benzofuran, benzothiophene, benzoxazole, and indole were synthesized. The fluorescence, bioluminescence, and kinetic pr

Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2-(3′,4′,5′-trimethoxybenzoyl)-3- aminobenzo[b]thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2-M phase of the cell cycle and induced apoptosis. In order to investigate the importance of the amino group at the 3-position of the benzo[b]thiophene skeleton, the corresponding 3-unsubstituted and methyl derivatives were prepared. A novel series of inhibitors of tubulin polymerization, based on the 2-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton with a methoxy substituent at the C-4, C-5, C-6 or C-7 position on the benzene ring, was evaluated for antiproliferative activity against a panel of five cancer cell lines, for inhibition of tubulin polymerization and for cell cycle effects. Replacing the methyl group at the C-3 position resulted in increased activity compared with the corresponding 3-unsubstituted counterpart. The structure-activity relationship established that the best activities were obtained with the methoxy group placed at the C-4, C-6 or C-7 position. Most of these compounds exhibited good growth inhibition activity and arrest K562 cells in the G2-M phase via microtubule depolymerization.