1113-92-4

Usage

Uses

Used in Flavor and Fragrance Industry:
Ethylmalonic acid dibutyl ester serves as a flavoring agent and fragrance ingredient, capitalizing on its fruity scent to enhance the aroma of various products.
Used in Industrial Applications as a Solvent:
In the industrial sector, Ethylmalonic acid dibutyl ester is utilized as a solvent due to its solubility in organic solvents, which makes it suitable for dissolving a wide range of substances in different processes.
It is important to handle Ethylmalonic acid dibutyl ester with care and adopt protective measures to ensure minimal exposure, given its classification as a low-toxicity chemical.

InChI:InChI=1/C13H24O4/c1-4-7-9-16-12(14)11(6-3)13(15)17-10-8-5-2/h11H,4-10H2,1-3H3

Upstream product

• 504-64-3 carbon suboxide 
• 75-03-6 ethyl iodide 
• 2372-45-4 sodium butanolate 
• 601-75-2 ethylmalonic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 2518-72-1 5-ethyl barbituric acid 

Relevant academic research and scientific papers

Multiplexed LC-MS/MS analysis of methylsuccinic acid, ethylmalonic acid, and glutaric acid in plasma and urine

Low molecular-mass aliphatic carboxylic acids are critically important for intermediate metabolism and may serve as important biomarkers for metabolic homeostasis. Here in, we focused on multiplexed method development of aliphatic carboxylic analytes, including methylsuccinic acid (MSA), ethylmalonic acid (EMA), and glutaric acid (GA). Also assessed was their utility in a population's health as well as metabolic disease screening in both plasma and urine matrices. MSA, EMA, and GA are constitutional isomers of dicarboxylic acid with high polarity and poor ionization efficiency, resulting in such challenges as poor signal intensity and retention, particularly in reversed-phase liquid chromatography with electrospray mass spectrometry (RP-LC-ESI-MS/MS). Derivatization using n-butanol was performed in the sample preparation to enhance the signal intensity accompanied with a positive charge from ionization in complicated biomatrices as well as to improve the separation of these isomers with optimal retention. Fit-for-purpose method validation results demonstrated quantitative ranges for MSA/EMA/GA from 5/10/20 ng/mL to 400 ng/mL in plasma analysis, and 100/200/100 ng/mL to 5000/10000/5000 ng/mL in urine analysis. This validated method demonstrates future utility when exploring population health analysis and biomarker development in metabolic diseases.