111422-90-3Relevant academic research and scientific papers
Copper and cobalt mediated regioselective alkylation of polyketide models: Methyl 3,5-dioxohexanoate and triacetic acid lactone
Cervello, Jordi,Marquet, Jorge,Moreno-Manas, Marcial
, p. 2035 - 2046 (2007/10/02)
Regioselective C-alkylations at the intercarbonyl positions C-4 and C-2 of the polyketide model methyl 3,5-dioxohexanoate, 1, have been acomplished through reactions of its cobalt(II), 4a, and copper(II), 4b, complexes respectively. Some examples of double alkylations at both positions are presented. Cyclizations of the regioselectively substituted diketoesters so prepared gave triacetic acid lactone derivatives regioselectively alkylated at C-5 and at C-3.
Cobalt Mediated Regioselective Alkylation of Methyl 3,5-Dioxohexanoate. Preparation of 5-Alkyl Derivatives of 4-Hydroxy-6-methyl-2-pyrone
Cervello, Jordi,Marquet, Jorge,Moreno-Manas, Marcial
, p. 644 - 645 (2007/10/02)
The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicycloundec-7-ene (DBU) to give 5-alkyl-4-hydroxy-
