111453-07-7

Upstream product

• 111453-06-6 4--4'-nitrodiphenylsulphide 
• 111453-03-3 4'-nitro-4-N-tosylaminodiphenyl sulfide 

Downstream Products

• 111453-08-8 4--4'-nitrodiphenylsulphone 
• 111452-84-7 5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine 
• 111452-86-9 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine 
• 111452-88-1 2,4-diamino-5-<4-<3-(4''-aminophenyl-4'-sulphonylphenylamino)propoxy>-3,5-dimethoxybenzyl>pyrimidine 
• 128076-26-6 5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine 
• 143489-50-3 4--4'-nitrodiphenylsulphone 

Relevant academic research and scientific papers

Synthesis of new 2,4-diamino-5-benzylpyrimidines active against various bacterial species

New inhibitors of mycobacterial dihydrofolate reductase (DHFR) have been developed.These compounds show high inhibitory activities against Gram-negative and mycobacterial DHFR exceeding that for the commercially available DHFR blockers.Amongst these compo

Substituted 2,4-diamino-5-benzylpyrimidines, their preparation and their use as medicaments with an antimicrobial activity

Novel substituted 2,4-diamino-5-benzyl pyrimidines are described. The novel substances have antimicrobial activity and are particularly suitable for inhibiting the growth of mycobacteria. Combined with inhibitors such as diaminodiphenylsulphones, ring-substituted 4-aminodiphenylsulphones or ring and/or nitrogen-substituted diaminodiphenylsulphones, they have a marked synergistic activity.