111462-16-9Relevant academic research and scientific papers
Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain-Soluble Support
Matsuno, Yuki,Shoji, Takao,Kim, Shokaku,Chiba, Kazuhiro
, p. 800 - 803 (2016)
A straightforward method for the synthesis of oligonucleotide blocks using a Cbz-type alkyl-chain-soluble support (Z-ACSS) attached to the 3′-OH group of 3′-terminal nucleosides was developed. The Z-ACSS allowed for the preparation of fully protected deox
SYNTHESIS AND CHARACTERIZATION OF A CARBAMATE-LINKED OLIGONUCLEOSIDE
Coull, James M.,Carlson, Dean V.,Weith, H. Lee
, p. 745 - 748 (1987)
Reaction of 5'-O-dimethoxytritylthymidine with 1,1'-carbonyldiimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 5'-amino-5'-deoxythymidine to produce a dinucleoside containing a 3'-O-5'-N-carbamoyl linkage.Four repetitions of carbonyl imidazolide formation and condensation produced a carbamate-linked hexamer.Hydrolytic and thermal denaturation studies did not indicate the presence of intramolecular base stacking.
3' PROTECTED NUCLEOTIDES
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Paragraph 0483, (2020/07/14)
The present disclosure provides 3' protected nucleotides, including those 3' protected nucleotides having a detectable tag. Systems and methods of sequencing nucleic acids using the 3' protected nucleotides are also disclosed, such as the sequencing of a nucleic acid using a nanopore or the sequencing of a nucleic acid via sequencing-by-synthesis.
Novel thermolabile protecting groups with higher stability at ambient temperature
Chmielewski, Marcin K.
supporting information; experimental part, p. 666 - 669 (2012/02/15)
Novel thermolabile hydroxyl protecting groups of increased thermostability are proposed. The stability of these groups at different temperatures ranges has been determined. The 2-pyridyl-N-(2,4-difluorobenzyl)aminoethyl unit was selected as stable at ambient temperature and very labile at increased temperature. The half-life times for the best groups were established. Application of this chemistry to the protection of different hydroxyl groups of thymidine was also demonstrated.
Synthesis of Fluorescent 3'-Carbamoyl Derivatives of Thymidine
Boreskov, Yu. G.,Berlin, Yu. A.
, p. 689 - 695 (2007/10/03)
Synthesis of a number of fluorescent thymidine 3'-urethanes was carried out by coupling of a corresponding 3'-carbonylimidazolide with aminoalkyl derivatives of fluorescein, aminophenylbenzoxazole, or pyrene. - Key words: fluorescent dyes; carbonyl diimidazole; urethanes; nucleosides
