111492-59-2

Basic information

• Product Name: C₂₂H₂₆NO₅P
• Synonyms: C₂₂H₂₆NO₅P
• CAS NO: 111492-59-2
• Molecular Weight: 415.426
• Mol File: 111492-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆NO₅P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆NO₅P(111492-59-2)
• EPA Substance Registry System: C₂₂H₂₆NO₅P(111492-59-2)

Safety Data

• Hazardous Substances Data: 111492-59-2(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 1499-21-4 Diphenylphosphinic chloride 

Downstream Products

• 111492-61-6 (S)-2-benzoylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 791-28-6 Triphenylphosphine oxide 

Relevant articles and documents

Asymmetric Synthesis of Optically Active threo- and erythro-Pyrrolidinylbenzyl Alcohol by the Highly Stereospecific Arylation of (S)-Proline and the Subsequent Highly Diastereoselective Reduction of the α-Amino Ketone

Optically active α-amino phenyl ketones in 92-94percent enantiomeric excess (e.e.) were obtained from the stereospecific arylation of (S)-proline or its derivatives by Friedel-Crafts reaction of by Grignard reaction.The subsequent complementary diastereoselective reductions of the α-amino ketone afforded respectively (S)- and (R)-α-benzyl alcohol in 93-100percent e.e. and in 100percent diastereoisomeric excess.The stereochemical course of the reduction of the α-amino ketone is discussed.