111492-62-7 Usage
Uses
Used in Organic Synthesis:
(S)-α-<(R)-pyrrolidin-2-yl>benzyl alcohol hydrochloride is used as a building block for the synthesis of complex organic molecules, particularly in the pharmaceutical industry. Its unique structure and reactivity make it a valuable component in creating a wide range of compounds with diverse applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (S)-α-<(R)-pyrrolidin-2-yl>benzyl alcohol hydrochloride is used as a key intermediate in the development of new drugs. Its chiral properties allow for the creation of enantiomerically pure compounds, which can have different biological activities and reduce potential side effects.
Used in Chiral Chromatography:
(S)-α-<(R)-pyrrolidin-2-yl>benzyl alcohol hydrochloride is used as a chiral resolving agent in chromatography. Its ability to form diastereomers with other chiral compounds makes it an essential tool in separating and identifying enantiomers, which is crucial in the development and quality control of chiral drugs.
Used in Biochemical Studies:
Due to its chiral nature, (S)-α-<(R)-pyrrolidin-2-yl>benzyl alcohol hydrochloride is utilized in various biochemical studies to investigate the interactions between chiral molecules and biological systems. This can lead to a better understanding of the role of chirality in biological processes and the development of more effective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 111492-62-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,4,9 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 111492-62:
(8*1)+(7*1)+(6*1)+(5*4)+(4*9)+(3*2)+(2*6)+(1*2)=97
97 % 10 = 7
So 111492-62-7 is a valid CAS Registry Number.
111492-62-7Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF CHIRAL PYROLLIDINE-2-YL- METHANOL DERIVATIVES
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Page/Page column 13; 15-16, (2018/09/26)
The invention relates to a novel process for the preparation of a chiral pyrollidine-2-yl-methanol derivative or a salt thereof of the formula (I), wherein R1 is aryl or heteroaryl and both aryl or heteroaryl are optionally substituted by C1-4-alkyl, halo-C1-4-alkyl, C1-4-alkoxy or halogen. The synthesis proceeds through an intermediate Weinreb amide, which is reacted with a Grignard reagent and hydrogenated. The chiral pyrollidine-2-yl-methanol derivatives of the formula (I) are versatile building blocks in the synthesis of pharmacologically active compounds, such as for the stereospecific synthesis of oligonucleotides carrying chiral phosphonate moieties.
Asymmetric Synthesis of Optically Active threo- and erythro-Pyrrolidinylbenzyl Alcohol by the Highly Stereospecific Arylation of (S)-Proline and the Subsequent Highly Diastereoselective Reduction of the α-Amino Ketone
Ookawa, Atsuhiro,Soai, Kenso
, p. 1465 - 1472 (2007/10/02)
Optically active α-amino phenyl ketones in 92-94percent enantiomeric excess (e.e.) were obtained from the stereospecific arylation of (S)-proline or its derivatives by Friedel-Crafts reaction of by Grignard reaction.The subsequent complementary diastereoselective reductions of the α-amino ketone afforded respectively (S)- and (R)-α-benzyl alcohol in 93-100percent e.e. and in 100percent diastereoisomeric excess.The stereochemical course of the reduction of the α-amino ketone is discussed.
