111495-26-2Relevant articles and documents
Asymmetric synthesis of (S)-(+)- and (R)-(-)-NZ-105 through the modified Michaelis-Arbuzov rearrangement as a key step
Kato, Tatsuhisa,Tejima, Mamiko,Ebiike, Hirosato,Achiwa, Kazuo
, p. 1132 - 1134 (2007/10/03)
The asymmetric synthesis of the (S)-(+)- and (R)-(-)-NZ-105 from the prochiral compound (1) was realized by using the modified Hunsdiecker reaction followed by the modified Michaelis-Arbuzov reaction with zerovalent palladium.
Lipase-catalyzed enantiosynthesis of (R)- and (S)-2- [benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2- yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ 105)
Ebiike,Yamazaki,Achiwa
, p. 1251 - 1253 (2007/10/03)
Homochiral 4-Aryl-1,4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active medic