1005-69-2

Basic information

• Product Name: 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane
• Synonyms: 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane
• CAS NO: 1005-69-2
• Molecular Formula: C₆H₁₃O₃P
• Molecular Weight: 164.139381
• EINECS: 213-739-0
• Mol File: 1005-69-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 140.7°Cat760mmHg
• Flash Point: 39.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 7.58mmHg at 25°C
• CAS DataBase Reference: 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane(1005-69-2)
• EPA Substance Registry System: 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane(1005-69-2)

Safety Data

• Hazardous Substances Data: 1005-69-2(Hazardous Substances Data)

Usage

General Description

2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane is a chemical compound with the molecular formula C6H13O3P. It is a colorless liquid with a molecular weight of 162.13 g/mol. 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane is often used as a solvent and in organic synthesis due to its ability to dissolve a wide range of organic compounds. It is also used as a reagent in various chemical reactions. Additionally, it has applications in the field of pharmaceuticals and agrochemicals. However, it is important to handle this compound with care as it can be harmful if ingested or inhaled, and can cause skin irritation upon contact.

InChI:InChI=1/C6H13O3P/c1-6(2)4-8-10(7-3)9-5-6/h4-5H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 2428-06-0 2-chloro-5,5-dimethyl-[1,3,2]dioxaphosphinane 
• 21458-75-3 2-diethylamino-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 111830-18-3 5,5-dimethyl-2-(N-ethyl-N-phenyl)amino-1,3,2-dioxaphosphorinane 
• 3279-26-3 methyl dichlorophosphite 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 21458-74-2 1-fluoro-4,4-dimethyl-1-phospha-2,6-dioxacyclohexane 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 139230-79-8 2-(1-ethyl-1,2-dihydropyridin-2-ylideneimino)-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 139230-78-7 2-(N-ethyl-2-pyridylamino)-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 139230-75-4 2-(2-pyridineamino)-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 83444-09-1 2-(imidazol-1-yl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 135474-14-5 2-(3,5-Dimethylpyrazol-1-yl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 15761-96-3 2-benzyl-5,5-dimethyl-1,3,2-dioxaphosphorinan-2-one 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 1005-96-5 2-methoxy-5,5-dimethyl-[1,3,2]dioxaphosphinane 2-oxide 
• 102969-01-7 2-methoxy-2-N-phenylimino-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 170308-21-1 (R)-5-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 
• 178484-41-8 (R)-5-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-1-methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 
• 178484-42-9 (S)-5-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-1-methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 
• 350589-51-4 2-(methoxy-phenyl-methyl)-5,5-dimethyl-[1,3,2]dioxaphosphinane 2-oxide 
• 15761-95-2 2-Oxo-2-triphenylmethyl-5,5-dimethyl-1,3,2-dioxaphosphorinan 
• 873-97-2 2,5,5-trimethyl-1,3,2-dioxaphosphorinan-2-one 
• 132868-57-6 (2-oxo-5,5-dimethyl-1,3,2-dioxaphosphorinanyl)(O,O-diphenyl phosphoryl)oxide 
• 132868-58-7 (5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinanyl)(p-toluenesulphonyl)oxide 
• 132868-54-3 2-N-benzoyl-N-phenylamino-2-oxo-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 4090-52-2 5,5,5',5'-tetramethyl-2,2'-oxy-bis-[1,3,2]dioxaphosphinane 2,2'-dioxide 

Relevant articles and documents

Synthesis and Utility of α-Methoxy Phosphonates with a 1,3,2-Dioxaphosphorinane Ring

Synthesis of several α-methoxy phosphonates with the phosphorus as a part of 1,3,2-dioxaphosphorinane ring by the simple reaction of (OCH 2CMe2CH2O)PCl with acetals is described. Analogous methoxy phosphonates using (±) (C20H 12O2)PCl were also synthesized using the same route. Utility of these phosphonates in the synthesis of vinyl ethers via the Horner-Wadsworth-Emmons [HWE] reaction is demonstrated.

Catalytic activity of amine hydrochlorides in alcoholysis of 2-N-ethylaniline-5,5-dimethyl-1,3,2-dioxaphosphorinane

The effect of acid-base properties of amine hydrochlorides on their catalytic activity has been studied in methanolysis of 2-N-ethylaniline-5,5-dimethyl-1,3,2-dioxaphosphorinane.Analysis of the Broensted correlation indicates general acid catalysis of phosphorylation.The nature of the alcoholysis of P(III) amides in the presence of amine hydrochlorides is discussed in terms of the general theory of acid catalysis.