1114960-39-2Relevant academic research and scientific papers
Facile and diastereoselective synthesis of β-acetamido ketones and keto esters via direct Mannich-type reaction
Mao, Hui,Wan, Jieping,Pan, Yuanjiang
, p. 1026 - 1032 (2009)
A Mannich-type three-component reaction involving aldehydes, acetamide, and enolizable ketones or β-keto esters for the preparation of β-acetamido carbonyl compounds in the presence of TMSCl is described. This newly developed protocol is operationally convenient, widely applicable, and highly diastereoselective.
