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Acetamide
Cas No: 60-35-5
No Data No Data No Data Xi'an ZB Biotech Co., Ltd. Contact Supplier
Acetamide Manufacturer/High quality/Best price/In stock
Cas No: 60-35-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity 60-35-5 Acetamide
Cas No: 60-35-5
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Acetamide
Cas No: 60-35-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Large Stock 99.0% Acetamide 60-35-5 Producer
Cas No: 60-35-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Acetamide
Cas No: 60-35-5
No Data 1 1 Ality Chemical Corporation Contact Supplier
acetamide
Cas No: 60-35-5
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Acetamide
Cas No: 60-35-5
USD $ 5.0-5.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
Acetamide
Cas No: 60-35-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 2000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
AcetamideCAS NO.:60-35-5
Cas No: 60-35-5
USD $ 1.0-2.0 / Gram 1 Gram 10000 Gram/Day Henan Wentao Chemical Product Co., Ltd. Contact Supplier

60-35-5 Usage

Uses

Cryoscopy; organic synthesis; general solvent; lacquers; explosives, soldering flux; wetting agent; plasticizer

Purification Methods

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]

General Description

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.

Waste Disposal

Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.

Potential Exposure

Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing

Reactivity Profile

Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).

Description

Acetamide (MEA or ethanamide),? the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot. Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings. ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

Fire Hazard

The flash point of Acetamide has not been determined, but Acetamide is probably combustible.

Carcinogenicity

The IARC has determined that there is sufficient evidence of carcinogenicity for acetamide in experimental animals and that it is possibly carcinogenic to humans.

Air & Water Reactions

Deliquescent. Very soluble in water.

Incompatibilities

Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.

Safety Profile

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.

Health Hazard

After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.

Uses

Acetamide is often used as plasticizer and as industrial solvent. molten acetamide is an excellent solvent for many organic and inorganic compounds. Solubilizer. renders sparingly soluble substances more soluble in water by mere addition or by fusion. stabilizer. manufacture of methylamine, denaturing alcohol. In organic syntheses. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.

storage

Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.

Precautions

During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Chemical Properties

Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.

Health Hazard

Mild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.

Chemical Properties

Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.
InChI:InChI=1/C2H5NO/c1-2(3)4/h1H3,(H2,3,4)

60-35-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A12589)  Acetamide, 99%    60-35-5 250g 220.0CNY Detail
Alfa Aesar (A12589)  Acetamide, 99%    60-35-5 1000g 728.0CNY Detail
Alfa Aesar (A12589)  Acetamide, 99%    60-35-5 5000g 2906.0CNY Detail
Sigma-Aldrich (89898)  Acetamide  analytical standard 60-35-5 89898-100MG 458.64CNY Detail

60-35-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name acetamide

1.2 Other means of identification

Product number -
Other names Acetic-d3 acid-d

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Acetamide is used as a solvent, plasticizer, and a wetting and penetrating agent.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60-35-5 SDS

60-35-5Synthetic route

acetonitrile
75-05-8

acetonitrile

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With manganese(IV) oxide; water In isopropyl alcohol at 70℃; under 5171.62 Torr; for 0.25h;99%
With C43H42Cl2NRu; water at 20℃; for 4h; Catalytic behavior;99%
With (PN3P)Ni(OH); water In tetrahydrofuran at 100℃; for 24h; Mechanism; Inert atmosphere; Schlenk technique; Sealed tube;99%
α-acetyl-γ-butyrolactone sodium

α-acetyl-γ-butyrolactone sodium

A

acetamide
60-35-5

acetamide

B

3-acetyl-2-oxo-4,5-dihydrofuran
517-23-7

3-acetyl-2-oxo-4,5-dihydrofuran

Conditions
ConditionsYield
With ethyl hydrazine hydrochloride In methanol at 10 - 20℃; for 2h; Temperature;A 98.9%
B 98.29%
C4H11NO2

C4H11NO2

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With sodium at 90℃; under 15001.5 Torr; for 6h; Reagent/catalyst; Temperature; Pressure; Time; Autoclave;98.5%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With ammonium hydroxide at 36℃; under 525.053 Torr; for 8h; Temperature; Pressure;98%
With ammonia; water
acetic acid
64-19-7

acetic acid

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With Candida antarctica lipase B; ammonium carbamate In various solvent(s) at 35℃; for 72h; Substitution;98%
With ammonia; zirconium(IV) oxide In benzene at 150℃;97%
With ammonium hydroxide; tin(IV) oxide at 200℃;3%
thioacetamide
62-55-5

thioacetamide

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With bismuth(III) nitrate In acetonitrile for 0.166667h; Heating;97%
With tetrabutylammonium periodite In dichloromethane at 20℃; for 0.0333333h;96%
With Oxone for 0.0833333h;95%
Chloroacetamide
79-07-2

Chloroacetamide

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With borohydride exchange resin; nickel diacetate In methanol for 1h; Ambient temperature;97%
C8H11NO2

C8H11NO2

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With sodium at 140℃; for 5h; Autoclave;96.2%
C9H13NO2

C9H13NO2

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With sodium at 140℃; for 4h; Autoclave;95.6%
N-(tert-butoxycarbonyl)acetamide
120157-98-4

N-(tert-butoxycarbonyl)acetamide

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 1h; Ambient temperature;95%
tris(2-acetoxyethyl)methane
87986-82-1

tris(2-acetoxyethyl)methane

A

acetamide
60-35-5

acetamide

B

3-(2-hydroxyethyl)pentane-1,5-diol
53378-75-9

3-(2-hydroxyethyl)pentane-1,5-diol

Conditions
ConditionsYield
Stage #1: tris(2-acetoxyethyl)methane With ammonia In methanol at 80℃; for 96h;
Stage #2: With ammonia at 80℃; for 24h;
A n/a
B 92.1%
Acetaldehyde oxime
107-29-9

Acetaldehyde oxime

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With [RuCl2(η2-C6H6){P(NMe2)3}]; water at 100℃; for 7h; Inert atmosphere; Sealed tube;92%
With nickel at 100℃;
bei der Belichtung;
With (ethylenediamine)palladium(II) dinitrate; water at 80℃; Inert atmosphere;
2,4,6-trimethyl-2-(2,4-dimethoxyphenyl)-1,2-dihydro-1,3,5-triazine
86774-75-6

2,4,6-trimethyl-2-(2,4-dimethoxyphenyl)-1,2-dihydro-1,3,5-triazine

A

acetamide
60-35-5

acetamide

B

N-acetylacetamide
625-77-4

N-acetylacetamide

C

2',4'-dimethoxyacetophenone
829-20-9

2',4'-dimethoxyacetophenone

Conditions
ConditionsYield
With sodium carbonate In water for 1.5h; Heating;A 2.5%
B 5%
C 91%
2-Acetylamino-2,3-dibromo-propionic acid

2-Acetylamino-2,3-dibromo-propionic acid

A

acetamide
60-35-5

acetamide

B

glyceric acid
473-81-4

glyceric acid

Conditions
ConditionsYield
With sodium hydroxide; sodium tetrahydroborate In water for 4h; Product distribution; pH=10.8-11.0;A n/a
B 90%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

A

acetamide
60-35-5

acetamide

B

3-phenyl-1H-quinolin-2-one
38035-81-3

3-phenyl-1H-quinolin-2-one

Conditions
ConditionsYield
With polyphosphoric acid at 80 - 100℃; for 1.5h;A n/a
B 90%
tetrafluoroboric acid diethyl ether
67969-82-8

tetrafluoroboric acid diethyl ether

F6P(1-)*C26H44Fe2NOS2(1+)

F6P(1-)*C26H44Fe2NOS2(1+)

acetonitrile
75-05-8

acetonitrile

A

acetamide
60-35-5

acetamide

B

F6P(1-)*C28H46Fe2N2S2(2+)*BF4(1-)

F6P(1-)*C28H46Fe2N2S2(2+)*BF4(1-)

Conditions
ConditionsYield
In acetone at 20℃; for 2h; Inert atmosphere; Schlenk technique;A 87%
B 90%
acetonitrile
75-05-8

acetonitrile

Benzaldoxime
932-90-1

Benzaldoxime

A

acetamide
60-35-5

acetamide

B

benzonitrile
100-47-0

benzonitrile

Conditions
ConditionsYield
With indium(III) nitrate at 100℃; for 18h;A n/a
B 89%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

1-isopropyl-4-(2-nitrovinyl)benzene
42139-37-7

1-isopropyl-4-(2-nitrovinyl)benzene

A

acetamide
60-35-5

acetamide

B

3-(4-isopropylphenyl)quinolin-2(1H)-one
1459775-45-1

3-(4-isopropylphenyl)quinolin-2(1H)-one

Conditions
ConditionsYield
With polyphosphoric acid at 80 - 100℃; for 1.5h;A n/a
B 89%
acetaldehyde
75-07-0

acetaldehyde

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With hydroxylamine hydrochloride; methanesulfonyl chloride In neat (no solvent) at 70℃; for 4h;88%
With hydroxylamine hydrochloride; C27H27ClIrNO; sodium hydrogencarbonate In dimethyl sulfoxide at 50℃; for 6h;88%
With [Ru(L1)Cl(CO)(PPh3)2]; hydroxylamine hydrochloride; sodium hydrogencarbonate In toluene for 12h; Catalytic behavior; Inert atmosphere; Reflux;78%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

1,2-dimethyl-4-(2-nitrovinyl)benzene
858467-52-4

1,2-dimethyl-4-(2-nitrovinyl)benzene

A

acetamide
60-35-5

acetamide

B

3-(3,4-dimethylphenyl)quinolin-2(1H)-one
1459775-46-2

3-(3,4-dimethylphenyl)quinolin-2(1H)-one

Conditions
ConditionsYield
With polyphosphoric acid at 80 - 100℃; for 1.5h;A n/a
B 88%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

1,2-dichloro-4-(2-nitrovinyl)benzene
37630-23-2, 18984-16-2

1,2-dichloro-4-(2-nitrovinyl)benzene

A

acetamide
60-35-5

acetamide

B

3-(3,4-dichloro-phenyl)quinolin-2(1H)-one
1459775-51-9

3-(3,4-dichloro-phenyl)quinolin-2(1H)-one

Conditions
ConditionsYield
With polyphosphoric acid at 80 - 100℃; for 1.5h;A n/a
B 88%
N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(3,4-dimethoxybenzylidene)rhodanine
65562-18-7

N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(3,4-dimethoxybenzylidene)rhodanine

A

acetamide
60-35-5

acetamide

B

N-β-D-glucopyranosylthiourea
76822-35-0

N-β-D-glucopyranosylthiourea

C

α-mercaptocinnamyl amide

α-mercaptocinnamyl amide

Conditions
ConditionsYield
With ammonia In methanol Ambient temperature;A n/a
B 87%
C n/a
5-ethoxycarbonyl-6-methyl-1,3-diacetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

5-ethoxycarbonyl-6-methyl-1,3-diacetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

A

acetamide
60-35-5

acetamide

B

5-ethoxycarbonyl-6-methyl-3-acetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
123043-99-2

5-ethoxycarbonyl-6-methyl-3-acetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With ammonia In tetrahydrofuran at 20℃;A 78%
B 86%
L-asparagine
70-47-3

L-asparagine

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With ammonium bromide In water for 15h; Electrochemical reaction;86%
ethanol
64-17-5

ethanol

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; ammonium hydroxide In water at 100℃; for 16h;85%
1,2-dimethylindole
875-79-6

1,2-dimethylindole

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

A

acetamide
60-35-5

acetamide

B

1-methyl-3-phenyl-1H-quinolin-2-one
2859-29-2

1-methyl-3-phenyl-1H-quinolin-2-one

Conditions
ConditionsYield
With polyphosphoric acid at 130℃;A n/a
B 84%
daidzein diacetate
3682-01-7

daidzein diacetate

A

acetamide
60-35-5

acetamide

Conditions
ConditionsYield
With ammonium formate; acetic acid; palladium hydroxide on carbon for 1.4h; Product distribution / selectivity; Heating / reflux;A n/a
B 83.2%
1-acetyl-2-phenylhydrazine
114-83-0

1-acetyl-2-phenylhydrazine

A

acetamide
60-35-5

acetamide

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; acetic acid under 2585.7 Torr; Product distribution; various phenylhydrazides, hydrogenolytic cleavage;A 82%
B n/a
With hydrogen; palladium In ethanol; acetic acid under 2585.7 Torr;A 82%
B n/a
With titanium tetrachloride; magnesium In diethyl ether; dichloromethane at 20℃; Inert atmosphere;A 63%
B 74%
acetamide
60-35-5

acetamide

Glyoxilic acid
298-12-4

Glyoxilic acid

N-acetyl-α-hydroxyglycine
63327-49-1

N-acetyl-α-hydroxyglycine

Conditions
ConditionsYield
In water; acetone for 18h; Heating / reflux;100%
In water
In acetone for 18h; Reflux;
acetamide
60-35-5

acetamide

iodobenzene
591-50-4

iodobenzene

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With acetamide; potassium phosphate; CuI In dodecane; ethyl acetate; toluene100%
With potassium phosphate; copper(l) iodide; L-arginine In 1,4-dioxane at 100℃; for 24h; Goldberg reaction;99%
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 5h;97%
acetamide
60-35-5

acetamide

1-bromo-3,5,7-trimethyladamantane
53398-55-3

1-bromo-3,5,7-trimethyladamantane

N-acetyl-3,5,7-trimethyl-1-aminoadamantane
15210-64-7

N-acetyl-3,5,7-trimethyl-1-aminoadamantane

Conditions
ConditionsYield
Heating;100%
acetamide
60-35-5

acetamide

2,2-dihydroxyacetic acid
563-96-2

2,2-dihydroxyacetic acid

N-acetyl-α-hydroxyglycine
63327-49-1

N-acetyl-α-hydroxyglycine

Conditions
ConditionsYield
In acetone for 20h; Heating;100%
In acetone
acetamide
60-35-5

acetamide

Methanesulfonic acid 2-{(2S,4R)-4-(2-azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl ester

Methanesulfonic acid 2-{(2S,4R)-4-(2-azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl ester

N-(2-{(2S,4R)-4-(2-Azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl)-acetamide

N-(2-{(2S,4R)-4-(2-Azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl)-acetamide

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
acetamide
60-35-5

acetamide

3-Hydroxy-2-thiophen-3-ylmethyl-2,3-dihydro-isoindol-1-one
176441-96-6

3-Hydroxy-2-thiophen-3-ylmethyl-2,3-dihydro-isoindol-1-one

N-(3-Oxo-2-thiophen-3-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

N-(3-Oxo-2-thiophen-3-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 48h; Heating;100%
acetamide
60-35-5

acetamide

3-Hydroxy-2-thiophen-2-ylmethyl-2,3-dihydro-isoindol-1-one
176441-95-5

3-Hydroxy-2-thiophen-2-ylmethyl-2,3-dihydro-isoindol-1-one

N-(3-Oxo-2-thiophen-2-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

N-(3-Oxo-2-thiophen-2-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 48h; Heating;100%
piperidine
110-89-4

piperidine

acetamide
60-35-5

acetamide

formaldehyd
50-00-0

formaldehyd

N-Piperidin-1-ylmethyl-acetamide

N-Piperidin-1-ylmethyl-acetamide

Conditions
ConditionsYield
With aluminum oxide In water for 0.2h; Condensation; microwave irradiation;100%
acetamide
60-35-5

acetamide

1,3-dibromo-5-fluorobenzene
1435-51-4

1,3-dibromo-5-fluorobenzene

N-(3-bromo-5-fluorophenyl)acetamide
807620-95-7

N-(3-bromo-5-fluorophenyl)acetamide

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 80℃; Inert atmosphere;100%
With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; potassium carbonate In toluene at 130℃; for 18h;76%
With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 105℃;44%
acetamide
60-35-5

acetamide

4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole
79483-05-9

4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A

ethylbis(dimethyl(2-penten-2-yl)silyloxy)borane
111869-87-5

ethylbis(dimethyl(2-penten-2-yl)silyloxy)borane

B

methylamine
74-89-5

methylamine

Conditions
ConditionsYield
In 1,2,5-trimethyl-benzene dropwise addn. of acetamide to boron compd. soln., 160°C, 3.5h; heating (reflux), 10h; evapn.; all under Ar; distn.; elem. anal.;A 100%
B 98%
acetamide
60-35-5

acetamide

2,3-pyrazinedicarboxylic anhydride
4744-50-7

2,3-pyrazinedicarboxylic anhydride

N-acetylpyrazine-2-carboxamide
135742-53-9

N-acetylpyrazine-2-carboxamide

Conditions
ConditionsYield
for 4h; Reflux;100%
caprolactam
105-60-2

caprolactam

acetamide
60-35-5

acetamide

Azepan-2-one; compound with acetamide

Azepan-2-one; compound with acetamide

Conditions
ConditionsYield
at 90℃; Inert atmosphere;100%
pyrrolidine
123-75-1

pyrrolidine

acetamide
60-35-5

acetamide

N-(acetyl)pyrrolidine
4030-18-6

N-(acetyl)pyrrolidine

Conditions
ConditionsYield
With Iron(III) nitrate nonahydrate In toluene for 24h; Reflux;100%
acetamide
60-35-5

acetamide

(R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine

(R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine

(R)-N-(3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)acetamide

(R)-N-(3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)acetamide

Conditions
ConditionsYield
Stage #1: acetamide; (R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine With caesium carbonate In dimethyl amine for 0.5h;
Stage #2: With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate at 120℃; for 0.666667h;
100%
acetamide
60-35-5

acetamide

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

Conditions
ConditionsYield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;99.3%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;83%
With potassium phosphate; 2-Phenyl-1,3,2-dioxaborinane In 1,4-dioxane at 115℃; for 30h; Inert atmosphere;28%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;
acetamide
60-35-5

acetamide

chlorobenzene
108-90-7

chlorobenzene

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Time; Inert atmosphere; Sonication;99.1%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;80%
With potassium phosphate; copper(l) iodide In N,N-dimethyl-formamide at 120℃; for 48h; Ullmann condensation;33%
With copper(l) iodide; potassium carbonate; pipecolic Acid In N,N-dimethyl-formamide at 110℃; for 30h; Goldberg coupling reaction;24%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Sonication;
acetamide
60-35-5

acetamide

3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

N-(1-acetylamino-3-phenylpropyl)acetamide
14473-58-6

N-(1-acetylamino-3-phenylpropyl)acetamide

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane for 2h; Heating;99%
With toluene-4-sulfonic acid at 100℃; for 1h; Neat (no solvent);99%
With toluene-4-sulfonic acid at 100℃; for 0.0166667h; Microwave irradiation; neat (no solvent);98%
acetamide
60-35-5

acetamide

butyraldehyde
123-72-8

butyraldehyde

1,1-bis-acetylamino-butane
7070-34-0

1,1-bis-acetylamino-butane

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane for 4h; Heating;99%
With acetic acid
With benzene Entfernen des entstehenden Wassers;
at 80 - 100℃;
With carbon monoxide; hydrogen; dicobalt octacarbonyl In ethyl acetate at 90 - 100℃;
acetamide
60-35-5

acetamide

benzylamine
100-46-9

benzylamine

N-(phenylmethyl)acetamide
588-46-5

N-(phenylmethyl)acetamide

Conditions
ConditionsYield
With nanosized zeolite beta In neat (no solvent) at 100℃; for 24h;99%
With [Ru-NHC] In toluene at 110℃; for 8h; Inert atmosphere; Schlenk technique; Sealed tube;98%
With H-β-zeolite In neat (no solvent) at 130℃; for 24h; Reagent/catalyst; Green chemistry;97%
acetamide
60-35-5

acetamide

carbon monoxide
201230-82-2

carbon monoxide

isovaleraldehyde
590-86-3

isovaleraldehyde

N-acetylleucine
99-15-0

N-acetylleucine

Conditions
ConditionsYield
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h;99%
With 1-methyl-pyrrolidin-2-one; sulfuric acid; lithium bromide; palladium on activated charcoal at 100℃; under 45003.6 Torr; for 12h;75%
With sulfuric acid; triphenylphosphine; lithium bromide; palladium on activated charcoal In 1-methyl-pyrrolidin-2-one; toluene at 90℃; under 45003.6 Torr; for 16h;64.4%
With 3-ethyl-1-methyl-1H-imidazol-3-ium bromide; triphenylphosphine; palladium(II) bromide at 100℃; under 45004.5 Torr; for 15h;63%
With hydrogenchloride; potassium tetrachloroplatinate; triphenylphosphine In 1,4-dioxane at 120℃; under 45600 Torr; for 15h;44%
acetamide
60-35-5

acetamide

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

acetylaminohydroxyacetic acid ethyl ester

acetylaminohydroxyacetic acid ethyl ester

Conditions
ConditionsYield
In tetrahydrofuran; toluene at 80℃; Inert atmosphere;99%
In toluene at 60 - 80℃; for 62h; Solvent; Temperature;87%
With acetic acid In n-heptane; Isopropyl acetate; toluene at 55 - 60℃; for 1h;85%
acetamide
60-35-5

acetamide

bis(trimethylsilyl)sulphate
18306-29-1

bis(trimethylsilyl)sulphate

A

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

B

N-(trimethylsilyl) acetimidate

N-(trimethylsilyl) acetimidate

C

acetonitrile
75-05-8

acetonitrile

D

acetamide sulfate

acetamide sulfate

Conditions
ConditionsYield
Dehydration; sulfation; silylation; Heating;A 69%
B 5%
C 94%
D 99%
acetamide
60-35-5

acetamide

ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

N-(2-methylphenyl)acetamide
120-66-1

N-(2-methylphenyl)acetamide

Conditions
ConditionsYield
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 8h;99%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In N,N-dimethyl-formamide at 80℃; for 23h;95%
With aluminum oxide; potassium fluoride; copper(l) iodide; N,N'-Dibenzylethylenediamine In toluene at 110℃; for 3h; Ullmann reaction; Inert atmosphere;90%
acetamide
60-35-5

acetamide

(5-bromo-1-methyl-1H-indol-2-yl)-(4-fluoro-phenyl)-methanone

(5-bromo-1-methyl-1H-indol-2-yl)-(4-fluoro-phenyl)-methanone

N-[2-(4-Fluoro-benzoyl)-1-methyl-1H-indol-5-yl]-acetamide

N-[2-(4-Fluoro-benzoyl)-1-methyl-1H-indol-5-yl]-acetamide

Conditions
ConditionsYield
Stage #1: acetamide; (5-bromo-1-methyl-1H-indol-2-yl)-(4-fluoro-phenyl)-methanone With copper(l) iodide; phosphate potassium salt In 1,4-dioxane for 0.333333h; Argon atmosphere;
Stage #2: With N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃;
99%
3-Chloropyridine
626-60-8

3-Chloropyridine

acetamide
60-35-5

acetamide

N-(pyridin-3-yl)acetamide
5867-45-8

N-(pyridin-3-yl)acetamide

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 4h;99%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;82%
acetamide
60-35-5

acetamide

4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 24h;99%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;92%
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium phosphate; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;84%
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique;50%
acetamide
60-35-5

acetamide

para-chlorotoluene
106-43-4

para-chlorotoluene

4-Methylacetanilide
103-89-9

4-Methylacetanilide

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 12h;99%
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h; Schlenk technique;81%
Stage #1: acetamide; para-chlorotoluene With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In acetonitrile for 0.00277778h; Inert atmosphere; Glovebox;
Stage #2: In acetonitrile at 200℃; for 1h; Microwave irradiation;
74%
acetamide
60-35-5

acetamide

2-Chloroanisole
766-51-8

2-Chloroanisole

2-methoxyacetanilide
93-26-5

2-methoxyacetanilide

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 7h;99%
With potassium phosphate; t-BuBrettPhos; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;91%
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