111509-71-8

Basic information

• Product Name: Ethyl 2-<methyl>-3-hydroxy-3-phenylpropionate
• Synonyms: Ethyl 2-<methyl>-3-hydroxy-3-phenylpropionate
• CAS NO: 111509-71-8
• Molecular Weight: 337.416
• Mol File: 111509-71-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethyl 2-<methyl>-3-hydroxy-3-phenylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-<methyl>-3-hydroxy-3-phenylpropionate(111509-71-8)
• EPA Substance Registry System: Ethyl 2-<methyl>-3-hydroxy-3-phenylpropionate(111509-71-8)

Safety Data

• Hazardous Substances Data: 111509-71-8(Hazardous Substances Data)

Upstream product

• 54424-07-6 Ethyl 3-propionate 
• 100-52-7 benzaldehyde 

Downstream Products

• 118210-35-8 trans-t-Butyl N-<(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)methyl>-N-methylcarbamate 
• 118210-35-8 cis-t-Butyl N-<(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)methyl>-N-methylcarbamate 
• 111509-76-3 Ethyl 3-methyl-2-oxo-6-phenyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-5-carboxylate 
• 111509-81-0 2-[(tert-Butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-3-phenyl-propionic acid ethyl ester 
• 111509-81-0 Ethyl 2-<methyl>-3-methylsulphonyloxy-3-phenylpropionate 
• 118210-33-6 erythro-t-Butyl N-<3-hydroxy-2-(hydroxymethyl)-3-phenyl>-N-methylcarbamate 
• 118210-33-6 threo-t-Butyl N-<3-hydroxy-2-(hydroxymethyl)-3-phenyl>-N-methylcarbamate 

Relevant articles and documents

Chemistry of Ethyl 2-methyl>-3-hydroxy-3-phenyl (or 3-vinyl)propionate: Mechanistic Considerations in the Formation of Tetrahydro-1,3-oxazin-2-ones

The threo- and erythro-selective aldol condensation of ethyl 3-propionate with benzaldehyde gave the benzylic alcohol-substituted aminopropionate ethyl 2-methyl>-3-hydroxy-3-phenylpropionate as a diastereoisomeric mixture.On treatment with methanesulphonyl chloride and triethylamine, the threo-isomer was converted into ethyl 3-methyl-2-oxo-6-phenyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-5-carboxylate, and the erythro-isomer gave simply its corresponding mesate derivative.The mechanism for this transformation is discussed.

A NEW SYNTHETIC METHOD OF 6-ARYL- OR VINYL-SUBSTITUTED 2-OXOTETRAHYDRO-1,3-OXAZINES

A novel transformation of benzylic or allylic hydroxy-substituted N-tert-butoxycarbonyl compounds by treatment with methanesulfonyl chloride in the presence of triethylamine into 2-oxotetrahydro-1,3-oxazines is described.