111524-96-0

Basic information

• Product Name: Carbamic acid, [(1S)-2-chloro-2-oxo-1-phenylethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS NO: 111524-96-0
• Molecular Formula: C23H18ClNO3
• Molecular Weight: 391.854
• Mol File: 111524-96-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-chloro-2-oxo-1-phenylethyl]-, 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-chloro-2-oxo-1-phenylethyl]-, 9H-fluoren-9-ylmethyl ester(111524-96-0)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-chloro-2-oxo-1-phenylethyl]-, 9H-fluoren-9-ylmethyl ester(111524-96-0)

Safety Data

• Hazardous Substances Data: 111524-96-0(Hazardous Substances Data)

Upstream product

• 102410-65-1 Fmoc-Phg-OH 

Downstream Products

• 111524-86-8 methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetamido)-3-phenylpropanoate 
• 329309-02-6 Fmoc-Phg-N₃ 

Relevant articles and documents

The synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing versatile chlorinating agent CPI-Cl

Racemization free synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing the versatile chlorinating reagent CPI-Cl has been described in one-pot. The present protocol has shown compability towards urethane protecting groups like Boc, Cbz and Fmoc, and side chain protections of amino acids showed complete tolerance.

HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of ss-casomorphin

A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAtDCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-VaI-GIy-VaI-OH (PGVGV), and ss-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively.

Synthesis of peptides mediated by potassium salt of 1-hydroxy-7-azabenzotriazole

The potassium salt of 1-hydroxy-7-azabenzotriazole can be used along with acid chlorides of 9-fluorenylmethyloxycarbonylamino acids as coupling agents in peptide bond formation.The acylation reactions are rapid and efficient and can be carried out in an organic medium.The yields as well as purity of the peptides are satisfactory.