1116-92-3Relevant academic research and scientific papers
Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes
Reznikov,Golovin,Klimochkin
, p. 663 - 667 (2013)
A new synthetic approach to (3R)-4-amino-3-methylbutyric acid and [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [(R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of dieth
The 5-exo-trig radical cyclization reaction under reductive and oxidative conditions in the synthesis of optically pure GABA derivatives
Rodríguez, Verónica,Sánchez, Mario,Quintero, Leticia,Sartillo-Piscil, Fernando
, p. 10809 - 10815 (2007/10/03)
Free radical precursors 4a and 4b were synthesized and treated under reductive or oxidative conditions to obtain the corresponding optically pure pyrrolidinones 5-8, which were subsequently transformed into corresponding optically pure GABA derivatives 9-11. When reductive radical conditions (4a→7 and 8) were used, a Ph1-5 migration product 14 was obtained; presumably depending upon the specific conformation of the rotamer precursor and also 14 was found to be a kinetic product.
CHEMOENZYMATIC SYNTHESIS OF (R)- AND (S)-4-AMINO-3-METHYLBUTANOIC ACIDS
Andruszkiewicz, Ryszard,Barret, Anthony G. M.,Silverman, Richard B.
, p. 159 - 166 (2007/10/02)
(R)- and (S)-4-Amino-3-methylbutanoic acids were synthesized in high yields via initial enantioselective hydrolysis of dimethyl 3-methylglutarate to methyl (R)-3-methylglutarate with pig liver esterase.The ester group was converted to an amine to give (R)-4-amino-3-methylbutanoic acid; the carboxylic acid was converted to an amine to give (S)-4-amino-3-methylbutanoic acid.
