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SYNTHESIS AND SPONTANEOUS DECOMPOSITION OF THE N-OXIDES OF DI(2-CHLOROALKYL)AMINOPHENYLALKANOIC ACIDS
Degutene, A.,Dzhyuvene, D.,Shukyalene, D.,Degutis, Yu.
, p. 1968 - 1972 (2007/10/02)
A convenient method was developed for the production of the N-oxides of di(2-chloroethyl)aminophenylalkanoic acids.In an acidic medium the main products from their spontaneous decomposition are the corresponding di(2-chloroalkyl)aminophenylalkanoic acids, while in an alkaline medium they are 2-chloroalkylaminophenylalkanoic acids and the simple aldehydes.The cleavage of the N-oxides of di(2-chloroethyl)aminophenylalkanoic acids leads to the formation of formaldehyde, whereas the dissociation of the di(2-chloropropyl)-N-oxide group gives a mixture of formaldehyde and acetaldehyde in a ratio of 1:1.The analogous N-oxides containing oxygen instead of the halogen atoms do not decompose under these conditions.
