111601-67-3

Upstream product

• 67-56-1 methanol 
• 26577-57-1 4-(morpholin-4-yl)phenylacetic acid 

Downstream Products

• 111601-69-5 picrate of methyl 4-morpholinophenylacetate N-oxide 
• 111601-70-8 hydrochloride of morpholinophenylacetic acid N-oxide 
• 111601-71-9 4-morpholinophenylacetic acid N-oxide 
• 372509-76-7 3-cyclopentyl-2-(4-morpholin-4-yl-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Para-aryl or heterocyclic substituted phenyl glucokinase activators

Para-aryl or heteroaryl substituted phenyl amides which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.

SYNTHESIS AND SPONTANEOUS DECOMPOSITION OF THE N-OXIDES OF DI(2-CHLOROALKYL)AMINOPHENYLALKANOIC ACIDS

A convenient method was developed for the production of the N-oxides of di(2-chloroethyl)aminophenylalkanoic acids.In an acidic medium the main products from their spontaneous decomposition are the corresponding di(2-chloroalkyl)aminophenylalkanoic acids, while in an alkaline medium they are 2-chloroalkylaminophenylalkanoic acids and the simple aldehydes.The cleavage of the N-oxides of di(2-chloroethyl)aminophenylalkanoic acids leads to the formation of formaldehyde, whereas the dissociation of the di(2-chloropropyl)-N-oxide group gives a mixture of formaldehyde and acetaldehyde in a ratio of 1:1.The analogous N-oxides containing oxygen instead of the halogen atoms do not decompose under these conditions.