111607-57-9

Basic information

• Product Name: 4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzene sulfonamide
• Synonyms: 4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzene sulfonamide
• CAS NO: 111607-57-9
• Molecular Weight: 391.494
• Mol File: 111607-57-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzene sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzene sulfonamide(111607-57-9)
• EPA Substance Registry System: 4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzene sulfonamide(111607-57-9)

Safety Data

• Hazardous Substances Data: 111607-57-9(Hazardous Substances Data)

Upstream product

• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 
• 4224-87-7 4-methyl-chalcone 
• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 4392-54-5 4-aminosulfonylphenylhydrazine 
• 111607-53-5 4-{N'-[(E)-1-Phenyl-3-p-tolyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide 

Downstream Products

• 111607-61-5 4-(3-phenyl-5-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents

Two series of sulfonamides were synthesized from 4-hydrazinylben-zenesulfonamide as the key starting material. 1,3,5-Triarylpyrazoline sulfonamides (2a-i) were obtained by cyclocondensation of various chalcones in 53-64 % yields, while 4-thiazolidinone derivatives (4a-e) were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62 % yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. Niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. Niger (MIC value at 12.5 μg mL-1) over the reference drug.

Synthesis, molecular docking study, and cytotoxic activity of 1,3,5-triaryl pyrazole derivatives

Synthesis, molecular docking study, and cytotoxic activity of a new group of 1,3,5-triaryl pyrazole derivatives were be studied. The antiproliferative activity of the final compounds were examined in MCF-7, AGS, HT-29 and NIH3T3 cell lines by MTT assay, u

Preparation and antidiabetic activity of new substituted 3,5-diarylpyrazolesulfonylurea derivatives II: Structure-activity relationship

Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypogl