1116136-36-7

Basic information

• Product Name: 1H-Pyrrolo[3,2-b]pyridine...
• Synonyms: 1H-Pyrrolo[3,2-b]pyridine 4-oxide;1H-Pyrrolo[3,2-b]pyridine-4-oxide4-Azaindole-N-oxide;4-azaindole-4-o×ide;1H-pyrrolo[3,2-b]pyridin-4-ium-4-olate
• CAS NO: 1116136-36-7
• Molecular Formula: C7H6N2
• Molecular Weight: 118.13594
• Mol File: 1116136-36-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 352.7±34.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 14.67±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[3,2-b]pyridine...(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,2-b]pyridine...(1116136-36-7)
• EPA Substance Registry System: 1H-Pyrrolo[3,2-b]pyridine...(1116136-36-7)

Safety Data

• Hazardous Substances Data: 1116136-36-7(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[3,2-b]pyridine is a heterocyclic chemical compound with a fused pyrrole and pyridine ring structure. It is a nitrogen-containing aromatic compound that is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its potential use in organic electronics and as a fluorescent probe for studying nucleic acids and proteins. The compound has attracted interest for its potential biological activities, including its ability to act as an inhibitor of certain enzymes and as a modulator of certain receptors in the central nervous system. Additionally, 1H-Pyrrolo[3,2-b]pyridine derivatives have been studied for their potential anticancer and antiviral activities.

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 

Downstream Products

• 1615714-04-9 N-(cyclopropylmethyl)-1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide 
• 1190312-40-3 3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine 
• 1615714-12-9 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine 
• 1615714-13-0 methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate 
• 1615714-14-1 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid 
• 1547041-34-8 7-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

4-Azaindole Derivatives

4-Azaindole derivatives which are modulators of muscarinic acetylcholine receptor (mAChR) M1 and which may be effective for the prevention or disease modifying or symptomatic treatment of cognitive deficits associated with neurological disorders such as Alzheimer-type dementia (AD) or dementia with Lewy bodies (DLB), and a pharmaceutical composition comprising a 4-azaindole derivative as an active ingredient.

Lead optimization of 1,4-azaindoles as antimycobacterial agents

In a previous report, we described the discovery of 1,4-azaindoles, a chemical series with excellent in vitro and in vivo antimycobacterial potency through noncovalent inhibition of decaprenylphosphoryl-β-d-ribose-2′- epimerase (DprE1). Nevertheless, high mouse metabolic turnover and phosphodiesterase 6 (PDE6) off-target activity limited its advancement. Herein, we report lead optimization of this series, culminating in potent, metabolically stable compounds that have a robust pharmacokinetic profile without any PDE6 liability. Furthermore, we demonstrate efficacy for 1,4-azaindoles in a rat chronic TB infection model. We believe that compounds from the 1,4-azaindole series are suitable for in vivo combination and safety studies.