1H-Pyrrolo[3,2-b]pyridine...

Base Information

• Chemical Name: 1H-Pyrrolo[3,2-b]pyridine...
• CAS No.: 1116136-36-7
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.13500
• Hs Code.: 2933990090
• Mol file: 1116136-36-7.mol

Synonyms:4-hydroxypyrrolo[3,2-b]pyridine;

Chemical Property of 1H-Pyrrolo[3,2-b]pyridine...

Chemical Property:

• Boiling Point: 352.7±34.0 °C(Predicted)
• PKA: 14.67±0.40(Predicted)
• PSA: 41.25000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 1.59640

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyrrolo[3,2-B]pyridine4-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[3,2-b]pyridine...

There total 1 articles about 1H-Pyrrolo[3,2-b]pyridine... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1H-pyrrolo[3,2-b]pyridine (272-49-1) → 1H-pyrrolo[3,2-b]pyridine 4-oxide (1116136-36-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

1H-pyrrolo[3,2-b]pyridine 4-oxide (1116136-36-7) → 1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine-7-carbonitrile

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 80 °C / Inert atmosphere

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

1H-pyrrolo[3,2-b]pyridine 4-oxide (1116136-36-7) → 7-chloro-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 80 °C / Inert atmosphere

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; trichlorophosphate; In dichloromethane; water;

upstream raw materials:

1H-pyrrolo[3,2-b]pyridine

Downstream raw materials:

N-(cyclopropylmethyl)-1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Refernces

• 1、 -. "BIARYL KINASE INHIBITORS". Page/Page column 195. . Retrieved 2017/07/31.
• 2、 -. "4-AZAINDOLE DERIVATIVES". Page/Page column 39; 40. . Retrieved 2015/04/22.