111627-55-5

Basic information

• Product Name: 1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone
• Synonyms: 1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone
• CAS NO: 111627-55-5
• Molecular Weight: 242.702
• Mol File: 111627-55-5.mol

Chemical Properties

• CAS DataBase Reference: 1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone(111627-55-5)
• EPA Substance Registry System: 1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone(111627-55-5)

Safety Data

• Hazardous Substances Data: 111627-55-5(Hazardous Substances Data)

Upstream product

• 493-33-4 1-(4-hydroxy-2-methoxy-phenyl)ethanone 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 111627-01-1 1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride 
• 131911-73-4 4-[Bis(4-fluorophenyl)methyl]-1-[3-(4-ethyl-2-methoxyphenoxy)-propyl]piperidine oxalate 
• 1005403-16-6 1-{2-methoxy-4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 131911-45-0 1-[4-[3-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone 

Relevant articles and documents

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment

A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.

Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.