111630-13-8

Basic information

• Product Name: phenyl p-tolylmethyl ketone O-methyloxime
• Synonyms: phenyl p-tolylmethyl ketone O-methyloxime
• CAS NO: 111630-13-8
• Molecular Weight: 239.317
• Mol File: 111630-13-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl p-tolylmethyl ketone O-methyloxime(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl p-tolylmethyl ketone O-methyloxime(111630-13-8)
• EPA Substance Registry System: phenyl p-tolylmethyl ketone O-methyloxime(111630-13-8)

Safety Data

• Hazardous Substances Data: 111630-13-8(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 35675-44-6 4-methylphenylacetyl chloride 

Downstream Products

• 30339-30-1 (S)-2-(4-methylphenyl)-1-phenylethylamine 
• 30339-32-3 (R)-1-phenyl-2-(p-tolyl)ethylamine 
• 30275-30-0 1-phenyl-2-(p-tolyl)ethylamine 
• 149365-93-5 (2,2-Diethoxy-ethyl)-(1-phenyl-2-p-tolyl-ethyl)-amine 

Relevant articles and documents

10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands

IDDC (3, 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene) and a series of substituted derivatives were synthesized and evaluated in vitro for their ability to displace tritiated MK-801 ([3H]-2) from its specific binding site in guinea pig brain homogenate. Substitution at the 3- position of 3 with bromine, chlorine, and fluorine led to increased binding affinity. In contrast, substitution of donor groups at the 3-position gave decreased binding affinities, as did all substitutions at the 7-position and on nitrogen. Where racemic mixtures were resolved, the (+)-optical antipodes were more active than their enantiomers or racemates. The most active ligand found in this study was (+)-13e (IC50 = 15.5 ± 4.5 nM). The affinity of (+)-13e for the PCP receptor makes it among the most potent ligands known. In vitro neuroprotection was demonstrated by 3, (+)-3, and (+)-6 (N-Me-IDDC) against glutamate-induced cell death in rat hippocampal cells.