30339-32-3

Basic information

• Product Name: α-phenyl-2-p-tolylethylamine
• Synonyms: α-phenyl-2-p-tolylethylamine;(R)-1-phenyl-(2-p-tolyl)ethylamine
• CAS NO: 30339-32-3
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.30218
• Mol File: 30339-32-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 317.8±11.0 °C(Predicted)
• Appearance: /
• Density: 1.037±0.06 g/cm3(Predicted)
• PKA: 8.89±0.10(Predicted)
• CAS DataBase Reference: α-phenyl-2-p-tolylethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-2-p-tolylethylamine(30339-32-3)
• EPA Substance Registry System: α-phenyl-2-p-tolylethylamine(30339-32-3)

Safety Data

• Hazardous Substances Data: 30339-32-3(Hazardous Substances Data)

Usage

Uses

(R)-1-Phenyl-2-(p-tolyl)ethylamine is a new resolving base for Ibuprofen (I140000); a selective cyclooxygenase inhibitor (IC50=14.9uM). Ibuprofen inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.

Upstream product

• 30275-30-0 1-phenyl-2-(p-tolyl)ethylamine 
• 492-41-1 (1R,2S)-norephedrine 
• 111630-13-8 phenyl p-tolylmethyl ketone O-methyloxime 

Relevant articles and documents

Peptide-catalyzed stereoselective conjugate addition reactions generating all-carbon quaternary stereogenic Centers

A powerful catalyst: Quaternary stereogenic centers adjacent to tertiary stereocenters were formed with high diastereoselectivities and enantioselectivities in conjugate addition reactions between aldehydes and β,β-disubstituted nitroolefins by using a peptidic catalyst (see scheme). γ-Amino acids and heterocyclic compounds bearing quaternary stereogenic centers are easily accessible from the products. Copyright

Practical resolution of 1-phenyl-2-(4-methylphenyl)ethylamine using a single resolving agent controlled by the dielectric constant of the solvent

A practical resolution of 1-phenyl-2-(4-methylphenyl)ethylamine 1 for obtaining (R)- and (S)-enantiomers by a dielectrically controlled resolution (DCR) method using a single resolving agent, (S)-mandelic acid 2, has been studied. The configuration of the excess enantiomer 1 in the less-soluble diastereomeric salt was found to vary depending on the solvent controlled by adjusting the solvent dielectric constant ε and the water content of the alcohol solvent. It was found that the presence of water molecules and the solvent molecular structures was key to controlling the configurational change phenomenon in the chiral discrimination between molecules 1 and 2. Moreover, the reaction environment controlled by the solvent dielectric constant plays a very distinct role in utilizing water molecules for crystallizing the less-soluble diastereomeric salt during the resolution. Based on the results, a practical resolution process for (R)-1 and (S)-1 production has been developed involving a simple solvent switch method; the (S)-1?(S)-2?H2O salt (33% yield, 96% de, E 64%) was obtained by the crystallization from 74% (w/w) aqueous ethanol in the first resolution, while the (R)-1?(S)-2 salt (23% yield, 98% de, E 46%) was crystallized from 100% ethanol of the condensate of the mother liquor after the first resolution.

ASYMMETRIC REDUCTION OF OXIME ETHERS. DISTINCTION OF ANTI AND SYN ISOMERS LEADING TO ENANTIOMERIC AMINES.

Anti and syn ketoxime ethers were reduced with a chiral reducing agent prepared from (-)-norephedrine and 2 eq of BH3 to give S and R amines respectively in up to 92percentee.The preferred absolute configuration of the amine was dependent on the geometry of the oxime ether.