111633-99-9Relevant academic research and scientific papers
Novel Copper-Containing Cytotoxic Agents Based on 2-Thioxoimidazolones
Krasnovskaya, Olga O.,Guk, Dmitry A.,Naumov, Alexey E.,Nikitina, Vita N.,Semkina, Alevtina S.,Vlasova, Kseniya Yu.,Pokrovsky, Vadim,Ryabaya, Oksana O.,Karshieva, Saida S.,Skvortsov, Dmitry A.,Zhirkina, Irina V.,Shafikov, Radik R.,Gorelkin, Petr V.,Vaneev, Alexander N.,Erofeev, Alexander S.,Mazur, Dmitrii M.,Tafeenko, Viktor A.,Pergushov, Vladimir I.,Melnikov, Mikhail Ya.,Soldatov, Mikhail A.,Shapovalov, Victor V.,Soldatov, Alexander V.,Akasov, Roman. A.,Gerasimov, Vasily M.,Sakharov, Dmitry A.,Moiseeva, Anna A.,Zyk, Nikolay V.,Beloglazkina, Elena K.,Majouga, Alexander G.
, p. 13031 - 13063 (2020/12/17)
A series of 73 ligands and 73 of their Cu+2 and Cu+1 copper complexes with different geometries, oxidation states of the metal, and redox activities were synthesized and characterized. The aim of the study was to establish the structure-activity relations
MECHANISM OF BASE-CATALYZED CYCLIZATION OF ETHYL N-(SUBSTITUTED AMINOCARBONYL)GLYCINATES
Mindl, Jaromir,Sterba, Vojeslav
, p. 156 - 161 (2007/10/02)
The cyclization rate constants have been measured of substituted ethyl N-(phenylaminocarbonyl)-, N-(alkylaminocarbonyl)-, and N-(phenylaminothiocarbonyl)glycinates RNHCXNHCH2CO2C2H5 (X=O,S).Logarithms of these constants increase with decreasing basicity of the amines down to the value of pKa(RNH2) = 5.5.The rate-limiting step of the reaction is formation of the tetrahedral intermediate.With ethyl N-(phenylaminocarbonyl)glycinates (whose pKa(RNH2) values are higher) this dependence, on the contrary, slightly decreases, and the acid-catalyzed splitting off of ethoxy group from the cyclic intermediate becomes rate-li miting.The cyclization rate of a series of ethyl N-(phenylaminothiocarbonyl)glycinates is practically independent of the pKa(RNH2) values, the change in the rate limiting step would take place at pH about 9.
