111652-28-9Relevant academic research and scientific papers
The Use of Crown Ethers in Peptide Chemistry. Part 1. Syntheses of Amino Acid Complexes with the Cyclic Polyether 18-Crown-6 and their Oligomerisation in Dicyclohexylcarbodi-imide-containing Solutions
Maascagni, Paolo,Hyde, Carolyn B.,Charalambous, Mario A.,Welham, Kevin J.
, p. 323 - 328 (2007/10/02)
The synthesis of amino acid complexes with the cyclic polyether 18-crown-6 and their solubility properties in organic solvents are described.Oligo homo-amino acid peptides have been prepared using the crown ether complexes and dicyclohexylcarbodi-imide as coupling agent.The mechanism leading to the formation of the oligopeptides has been discussed and proved to involve the transferring of one N-H proton from the crown ether complex to the carbodi-imide nitrogen.
