4321-58-8

Basic information

• Product Name: ε-Aminocaproic Acid Hydrochloride
• Synonyms: ε-Aminocaproic Acid Hydrochloride ;6-AMinohexanoic acid hydrochloride;e-Aminocaproic Acid Hydrochloride
• CAS NO: 4321-58-8
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.63386
• Product Categories: Aliphatics;Amines
• Mol File: 4321-58-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 128-129°
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: ε-Aminocaproic Acid Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ε-Aminocaproic Acid Hydrochloride(4321-58-8)
• EPA Substance Registry System: ε-Aminocaproic Acid Hydrochloride(4321-58-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• TSCA: No
• Hazardous Substances Data: 4321-58-8(Hazardous Substances Data)

Usage

Uses

ε-AMinocaproic Acid Hydrochloride can be used in the preparatiom of esters of 6-aminohexanoic acid

Upstream product

• 70288-80-1 6-methoxycarbonylaminohexanoic acid methyl ester 
• 5180-73-4 6-(Ethoxycarbonylamino)hexansaeure-ethylester 
• 105-60-2 caprolactam 
• 7647-01-0 hydrogenchloride 
• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 5100-36-7 6-isocyanato-hexanoic acid ethyl ester 
• 14273-90-6 methyl 6-bromohexanoate 
• 29640-13-9 methyl 6-isocyanatohexanoate 
• 60-32-2 6-aminohexanoic acid 

Downstream Products

• 60-32-2 6-aminohexanoic acid 
• 5100-26-5 6-<3-(4-Ethoxy-phenyl)-ureido>-hexansaeure- 
• 5100-18-5 6-(3-Phenyl-ureido)-hexansaeure-anilid 
• 5100-25-4 N-Methyl-6-isocyanato-hexansaeure-anilid 
• 39874-56-1 dodecyl 6-aminohexanoate 
• 16625-94-8 octyl 6-aminohexanoate 
• 372-52-1 6-amino-n-caproic acid n-hexyl ester 
• 14183-89-2 6-(5-anilinomethylene-4-oxo-2-thioxo-thiazolidin-3-yl)-hexanoic acid isopropyl ester 
• 14253-86-2 6-(5-anilinomethylene-4-oxo-2-thioxo-thiazolidin-3-yl)-hexanoic acid ethyl ester 
• 14183-91-6 6-[5-(N-acetyl-anilinomethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-hexanoic acid isopropyl ester 
• 14183-90-5 6-[5-(N-acetyl-anilinomethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-hexanoic acid ethyl ester 
• 42771-37-9 6-(3,4,5-Trimethoxy-benzenesulfonylamino)-hexanoic acid 
• 75980-37-9 ω-aminocaproic acid octyl ester hydrochloride 
• 111652-28-9 6-aminohexanoicacid hydrochloride complex 

Relevant articles and documents

ESTERS OF AMINO CARBOXYLIC ACIDS AND A PROCESS TO PREPARE THEM

The present invention relates to a process to prepare esters of an amino carboxylic acid of the formula (I) wherein R is an alkyl group containing 5 to 16 carbon atoms that may be branched or linear, k is a value of 1 to 3, m is an integer from 0 to 25, A is -CH2-CH2- or - CH2CH(CH3)- or -CH2-CH(CH2-CH3)-, n is an integer of at least 3 and at most 8, each R1 is a hydrogen atom, each R2 is independently a hydrogen atom or methyl or ethyl group, preferably each R2 is a hydrogen atom, and wherein X is an anion derivable from deprotonating a Br?nsted-Lowry acid comprising the steps of reacting an aminocarboxylic acid present as a cyclic amide of the formula (II) and an alkanol of the formula R-(0-A)mOH in the presence of the Br?nsted-Lowry acid at a temperature of between 60 and 200 degrees C wherein the total molar amount of aminocarboxylic acid to the molar amount of the alkanol is between 1 :0.8 and 1 :1.5 and wherein the Br?nsted-Lowry acid is not added to the reaction mixture until least 50% of the total of the alkanol and cyclic amide are added to the reaction mixture.

ISOLATION AND PURIFICATION OF 6-AMINOCAPROIC ACID

The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.

Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation

Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.