1116571-80-2Relevant academic research and scientific papers
Azabicyclic sulfonamides as potent 11β-HSD1 inhibitors
Shah, Unmesh,Boyle, Craig D.,Chackalamannil, Samuel,Baker, Hana,Kowalski, Timothy,Lee, Julie,Terracina, Giuseppe,Zhang, Lili
scheme or table, p. 1551 - 1554 (2010/06/16)
Inhibition of 11β-HSD1 has demonstrated potential in the treatment of various components of metabolic syndrome. We wish to report herein the discovery of novel azabicyclic sulfonamide based 11β-HSD1 inhibitors. Highly potent compounds exhibiting inhibitor
SUBSTITUTED BICYCLIC PIPERIDINYL-AND PIPERAZINYL- SULFONAMIDES USEFUL TO INHIBIT 11β-HYDROXYSTEROID DEHYDROGENASE TYPE-1
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Page/Page column 54, (2009/04/25)
In its many embodiments, the present invention relates to a novel class of substituted bicyclic piperidinyl- and piperazinylsulfonamide compounds useful to inhibit 11β-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11β-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.
