111663-96-8Relevant academic research and scientific papers
Studies of multicomponent Kinugasa reactions in aqueous media
McKay, Craig S.,Kennedy, David C.,Pezacki, John Paul
, p. 1893 - 1896 (2009)
Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a 'single pot' for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45-85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.
