111675-16-2Relevant academic research and scientific papers
INTRAMOLECULAR PHOSPHINE-DIRECTED HYDROFORMYLATION. APPLICATION TO THE TOTAL SYNTHESIS OF (+)-PHYLLANTHOCIN
Burke, Steven D.,Cobb, Jeffery E.
, p. 4237 - 4240 (1986)
The temporary incorporation of a coordinating phosphine residue into the tetracyclic phyllanthocin precursor 1a directed the 2-catalyzed hydroformylation of 1d largely to the desired C(3) position .This "intramolecular hydroformylation" strategy substantially improves a key transformation in the total synthesis of (+)-phyllanthocin.
