
Tetrahedron Letters p. 4237 - 4240 (1986)
Update date:2022-09-26
Topics:
Burke, Steven D.
Cobb, Jeffery E.
The temporary incorporation of a coordinating phosphine residue < m-(Ph2P)C6H4CO> into the tetracyclic phyllanthocin precursor 1a directed the <(COD)RhOAc>2-catalyzed hydroformylation of 1d largely to the desired C(3) position .This "intramolecular hydroformylation" strategy substantially improves a key transformation in the total synthesis of (+)-phyllanthocin.
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